Quantum dots: an insight and perspective of their biological interaction and how this relates to their relevance for clinical use.
Quantum dots: an insight and perspective of their biological interaction and how this relates to their relevance for clinical use.
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作者：
Clift MJ;Stone V
由于其新颖的物理化学特性，半导体纳米晶体量子点（QD）为众多不同的消费和医疗应用提供了有利的前景。量子点最显着的潜在应用是它们在纳米医学中作为治疗和诊断工具的用途。尽管量子点带来了许多好处，但拟议的、有意接触人类的做法引起了人们对其对人类健康潜在影响的担忧。这些担忧主要基于量子点的异质成分，最常见的是由镉基核和硫化锌壳组成。虽然其他纳米颗粒 (NP) 类型具有与 QD 类似的结构（即核壳技术（例如 Fe2O3、Au 和超顺磁性氧化铁 NP）），但围绕人类暴露于 QD 的担忧的重要性进一步放大，因为由于 QD 复杂的化学和发光特性，在任何（纳米）医疗环境/应用中使用这些 NP 可以被认为是现实的，而不仅仅是一种有利的可能性。因此，迫切需要彻底了解量子点如何与各种生物系统（主要是与人类相关的生物系统）相互作用，以及这种相互作用的后果是什么。本次综述的目的是强调量子点-生物系统相互作用的当前知识库，其中知识差距（仍然）仍然存在，以及对这种相互作用的理解如何与量子点最显着的应用相关；他们的临床相关性。
Due to their novel physico-chemical characteristics, semi-conductor nanocrystal quantum dots (QDs) provide an advantageous perspective towards numerous different consumer and medical applications. The most notable potential application of QDs is their use as therapeutic and diagnostic tools in nanomedicine. Despite the many benefits posed by QDs, the proposed, intentional exposure to humans has raised concerns towards their potential impact upon human health. These concerns are predominantly based upon the heterogeneous composition of QDs, which most commonly comprises of a cadmium-based core and zinc sulphide shell. Whilst other nanoparticle (NP) types possess a similar structure to QDs (i.e. core-shell technology (e.g. Fe2O3, Au and superparamagnetic iron oxide NPs)), the importance of the concerns surrounding human exposure to QDs is amplified further since, due to the sophisticated chemical and light-emitting properties of QDs, the use of these NPs within any (nano)medical setting/application could be suggested as realistic, rather than simply an advantageous possibility. It is therefore imperative that a thorough understanding of how QDs interact with various biological systems, predominantly those relative to humans and what the consequences of such interactions are is gained with extreme alacrity. It is the aim of this review to highlight the current knowledge base of QD-biological system interactions, where the knowledge gaps (still) remain and how the understanding of this interaction relates to the most notable of applications for QDs; their clinical relevance.
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