Central auditory dysfunction as a harbinger of Alzheimer dementia.
Central auditory dysfunction as a harbinger of Alzheimer dementia.
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DOI：
10.1001/archoto.2011.28
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发表时间：
2011-04
影响因子：
--
通讯作者：
Larson, Eric B.
中科院分区：
文献类型：
--
作者：
Gates, George A.;Anderson, Melissa L.;McCurry, Susan M.;Feeney, M. Patrick;Larson, Eric B.
确认中枢听觉功能障碍可能是阿尔茨海默病 (AD) 发病的先兆 队列研究 研究中心对来自痴呆症监测队列的 274 名志愿者进行了长达 4 年的随访，在完成听力评估后。 21 名参与者在听力测试后得到了 AD 的共识诊断。进行了三个中央听觉测试：双分句子识别、双分数字和同侧竞争信息的合成句子识别。在一次共识会议上，使用国家神经和通讯疾病研究所以及中风-阿尔茨海默氏病和相关疾病协会的标准对阿尔茨海默病进行了新的诊断。每次 CAD 测试的平均分数在痴呆组中显着较差。以年龄为时间尺度的 Cox 比例风险模型用于根据 CAD 测试结果估计痴呆事件的风险比。根据教育水平进行调整后，根据自由报告模式下的二元句子识别，严重 CAD 患者发生痴呆的风险比<50% 为 9.9（95% C.I. 3.6, 26.7）。在这些情况下，CAD 是阿尔茨海默氏痴呆症的先兆。我们建议通过 CAD 测试来评估抱怨听力困难的老年人。患有严重 CAD 的患者应接受修改后的康复计划，并考虑转诊进行神经系统评估。
Confirm that central auditory dysfunction may be a precursor to the onset of Alzheimer’s Disease (AD) Cohort study Research study center 274 volunteers from a dementia surveillance cohort were followed for up to 4 years after having complete audiometric assessment. 21 of the participants received a consensus diagnosis of AD after hearing testing. Three central auditory tests were performed: the Dichotic Sentence Identification, the Dichotic Digits, and the Synthetic Sentence Identification with Ipsilateral Competing Message. A new diagnosis of Alzheimer’s disease using the National Institute of Neurological and Communicative Diseases and Stroke–Alzheimer’s Disease and Related Disorders Association criteria at a consensus conference The mean scores on each CAD test were significantly poorer in the incident dementia group. Cox proportional hazards models with age as the time-scale were used to estimate the hazard ratio for incident dementia based on CAD test results. After adjusting for educational level, the hazard ratio for incident dementia in people with severe CAD based on a Dichotic Sentence Identification in free report mode of <50% was 9.9 (95% C.I. 3.6, 26.7). In these cases, CAD was a precursor to Alzheimer’s dementia. We recommend evaluating older adults complaining of hearing difficulty with CAD tests. Those with severe CAD should receive a modified rehabilitation program and be considered for referral for neurologic evaluation.
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