Lung Histopathology in Coronavirus Disease 2019 as Compared With Severe Acute Respiratory Sydrome and H1N1 Influenza: A Systematic Review.
Lung Histopathology in Coronavirus Disease 2019 as Compared With Severe Acute Respiratory Sydrome and H1N1 Influenza: A Systematic Review.
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DOI：
10.1016/j.chest.2020.09.259
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发表时间：
2021-01
期刊：
影响因子：
9.6
通讯作者：
Mino-Kenudson M
中科院分区：
文献类型：
--
作者：
Hariri LP;North CM;Shih AR;Israel RA;Maley JH;Villalba JA;Vinarsky V;Rubin J;Okin DA;Sclafani A;Alladina JW;Griffith JW;Gillette MA;Raz Y;Richards CJ;Wong AK;Ly A;Hung YP;Chivukula RR;Petri CR;Calhoun TF;Brenner LN;Hibbert KA;Medoff BD;Hardin CC;Stone JR;Mino-Kenudson M
严重冠状病毒病2019(新冠肺炎)患者呼吸衰竭伴低氧血症和急性双侧肺浸润性疾病，与急性呼吸窘迫综合征一致。新冠肺炎呼吸衰竭可能代表了一种新的病理实体。新冠肺炎中描述的肺组织病理学与SARS和H1N1流感中描述的肺组织病理学相比如何？我们进行了一项系统的回顾，以确定新冠肺炎的肺组织病理学特征，并将其与其他最近的病毒大流行，H1N1流感和SARS的结果进行比较。我们系统地检索MEDLINE和PubMed2020年6月24日之前发表的研究，检索词新冠肺炎、H1N1流感和SARS，并限定词为病理学、活检和尸检。使用PRISMA-个体参与者数据指南，我们的系统综述分析包括代表171名新冠肺炎患者的26篇文章；代表287名H1N1患者的20篇文章；以及代表SARS患者的8篇文章。在新冠肺炎，88%的患者报告了急性期弥漫性肺泡损伤(DAD)，这与H1N1流感和SARS中DAD的比例(90%)和SARS(98%)相似。57%的新冠肺炎患者和58%的SARS患者报告有肺微血栓，而H1N1流感患者的这一比例为24%。DAD是新冠肺炎、H1N1流感和SARS患者肺部病理中发现的主要组织病理学模式，与ARDS的组织学相关。与H1N1流感相比，新冠肺炎和SARS患者报告的微血栓发生率都更高。还需要进一步的工作来验证这一组织病理学发现，如果得到证实，则阐明其机制基础，并描述与临床重要结果的任何关联。
Patients with severe coronavirus disease 2019 (COVID-19) have respiratory failure with hypoxemia and acute bilateral pulmonary infiltrates, consistent with ARDS. Respiratory failure in COVID-19 might represent a novel pathologic entity. How does the lung histopathology described in COVID-19 compare with the lung histopathology described in SARS and H1N1 influenza? We conducted a systematic review to characterize the lung histopathologic features of COVID-19 and compare them against findings of other recent viral pandemics, H1N1 influenza and SARS. We systematically searched MEDLINE and PubMed for studies published up to June 24, 2020, using search terms for COVID-19, H1N1 influenza, and SARS with keywords for pathology, biopsy, and autopsy. Using PRISMA-Individual Participant Data guidelines, our systematic review analysis included 26 articles representing 171 COVID-19 patients; 20 articles representing 287 H1N1 patients; and eight articles representing 64 SARS patients. In COVID-19, acute-phase diffuse alveolar damage (DAD) was reported in 88% of patients, which was similar to the proportion of cases with DAD in both H1N1 (90%) and SARS (98%). Pulmonary microthrombi were reported in 57% of COVID-19 and 58% of SARS patients, as compared with 24% of H1N1 influenza patients. DAD, the histologic correlate of ARDS, is the predominant histopathologic pattern identified in lung pathology from patients with COVID-19, H1N1 influenza, and SARS. Microthrombi were reported more frequently in both patients with COVID-19 and SARS as compared with H1N1 influenza. Future work is needed to validate this histopathologic finding and, if confirmed, elucidate the mechanistic underpinnings and characterize any associations with clinically important outcomes.
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DOI：
10.1590/s1807-59322010001200003
发表时间：
2010
期刊：
Clinics (Sao Paulo, Brazil)
影响因子：
--
作者：
Capelozzi VL;Parra ER;Ximenes M;Bammann RH;Barbas CS;Duarte MI
通讯作者：
Duarte MI
影响因子：
50.5
作者：
Hajjar, L. A.;Mauad, T.;Hoff, P. M.
通讯作者：
Hoff, P. M.
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
影响因子：
3.3
作者：
Franks TJ;Chong PY;Chui P;Galvin JR;Lourens RM;Reid AH;Selbs E;McEvoy CP;Hayden CD;Fukuoka J;Taubenberger JK;Travis WD
通讯作者：
Travis WD
影响因子：
1.1
作者：
Craver, Randall;Huber, Samantha;Finger, Leron
通讯作者：
Finger, Leron