Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore.
Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore.
复制标题
DOI：
10.1016/s0046-8177(03)00367-8
复制
发表时间：
2003-08
期刊：
影响因子：
3.3
通讯作者：
Travis WD
中科院分区：
文献类型：
--
作者：
Franks TJ;Chong PY;Chui P;Galvin JR;Lourens RM;Reid AH;Selbs E;McEvoy CP;Hayden CD;Fukuoka J;Taubenberger JK;Travis WD
严重急性呼吸系统综合症（SARS）是一种由SARS相关冠状病毒（SARS- cov）引起的传染病，SARS- cov是冠状病毒科的新成员。为了评估这种危及生命的呼吸道疾病的肺部病理，我们研究了2003年春季新加坡爆发期间死于SARS的8名患者的尸检肺切片。8例肺损伤均以弥漫性肺泡损伤为主。组织学根据病程的不同而不同。持续10天或更短时间的病例表现为急性期弥漫性肺泡损伤（DAD），空域水肿和细支气管纤维蛋白。病程超过10天的患者表现为组织期DAD、II型肺细胞增生、鳞状化生、多核巨细胞、急性支气管肺炎。急性期DAD，肺泡壁透明膜全细胞角蛋白染色呈阳性，突出显示肺细胞缺失。泛细胞角蛋白、甲状腺转录因子-1和CD68染色显示多核细胞既为II型肺细胞，也为巨噬细胞。8例新鲜尸检组织中有7例和8例福尔马林固定石蜡包埋肺组织中有8例检测到SARS-CoV RNA，其中新鲜组织中有1例阴性。了解SARS患者DAD的病理变化可为制定治疗策略提供依据。对SARS发病机制的进一步研究可能揭示DAD发病机制的新见解。
Severe acute respiratory syndrome (SARS) is an infectious condition caused by the SARS-associated coronavirus (SARS-CoV), a new member in the family Coronaviridae. To evaluate the lung pathology in this life-threatening respiratory illness, we studied postmortem lung sections from 8 patients who died from SARS during the spring 2003 Singapore outbreak. The predominant pattern of lung injury in all 8 cases was diffuse alveolar damage. The histology varied according to the duration of illness. Cases of 10 or fewer days’ duration demonstrated acute-phase diffuse alveolar damage (DAD), airspace edema, and bronchiolar fibrin. Cases of more than 10 days’ duration exhibited organizing-phase DAD, type II pneumocyte hyperplasia, squamous metaplasia, multinucleated giant cells, and acute bronchopneumonia. In acute-phase DAD, pancytokeratin staining was positive in hyaline membranes along alveolar walls and highlighted the absence of pneumocytes. Multinucleated cells were shown to be both type II pneumocytes and macrophages by pancytokeratin, thyroid transcription factor-1, and CD68 staining. SARS-CoV RNA was identified by reverse transcriptase-polymerase chain reaction in 7 of 8 cases in fresh autopsy tissue and in 8 of 8 cases in formalin-fixed, paraffin-embedded lung tissue, including the 1 negative case in fresh tissue. Understanding the pathology of DAD in SARS patients may provide the basis for therapeutic strategies. Further studies of the pathogenesis of SARS may reveal new insight into the mechanisms of DAD.
登录
查看更多内容
影响因子：
5.2
作者：
MERTSOLA, J;ZIEGLER, T;HALONEN, P
通讯作者：
HALONEN, P
影响因子：
56.9
作者：
Taubenberger, JK;Reid, AH;Fanning, TG
通讯作者：
Fanning, TG
影响因子：
6.4
作者：
MCINTOSH, K;CHAO, RK;MUFSON, MA
通讯作者：
MUFSON, MA
DOI：
10.1016/s0140-6736(03)13413-7
发表时间：
2003-05-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nicholls JM;Poon LL;Lee KC;Ng WF;Lai ST;Leung CY;Chu CM;Hui PK;Mak KL;Lim W;Yan KW;Chan KH;Tsang NC;Guan Y;Yuen KY;Peiris JS
通讯作者：
Peiris JS
影响因子：
5.1
作者：
MCINTOSH, K;ELLIS, EF;FULGINITI, VA
通讯作者：
FULGINITI, VA