Somatosensory cortices are required for the acquisition of morphine-induced conditioned place preference.
Somatosensory cortices are required for the acquisition of morphine-induced conditioned place preference.
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DOI：
10.1371/journal.pone.0007742
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发表时间：
2009-11-03
期刊：
影响因子：
3.7
通讯作者：
Ma Y
中科院分区：
文献类型：
--
作者：
Meng Z;Liu C;Hu X;Ma Y
感觉系统信息被认为在药物成瘾相关反应中起重要作用。然而，躯体感觉信息如何参与药物相关行为尚不清楚。许多研究表明，药物成瘾是一种病理性篡夺学习和记忆的神经机制，通常与追求奖励有关。因此，阐明躯体感觉在药物相关学习记忆中的作用，对于理解药物成瘾的神经生物学机制具有重要意义。在本研究中，我们利用条件位置偏好模型探讨了躯体感觉系统在奖励相关联想学习中的作用。在条件反射训练之前或之后，在体感觉皮层造成损伤。我们发现，在吗啡条件反射前而非吗啡条件反射后，躯体感觉皮层的损伤损害了位置偏好的习得。这些结果表明，体感觉皮层对吗啡诱导的位置偏好的习得是必需的，而不是保留。
Sensory system information is thought to play an important role in drug addiction related responses. However, how somatic sensory information participates in the drug related behaviors is still unclear. Many studies demonstrated that drug addiction represents a pathological usurpation of neural mechanisms of learning and memory that normally relate to the pursuit of rewards. Thus, elucidate the role of somatic sensory in drug related learning and memory is of particular importance to understand the neurobiological mechanisms of drug addiction. In the present study, we investigated the role of somatosensory system in reward-related associative learning using the conditioned place preference model. Lesions were made in somatosensory cortices either before or after conditioning training. We found that lesion of somatosensory cortices before, rather than after morphine conditioning impaired the acquisition of place preference. These results demonstrate that somatosensory cortices are necessary for the acquisition but not retention of morphine induced place preference.
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影响因子：
15.9
作者：
Naqvi, Nasir H.;Bechara, Antoine
通讯作者：
Bechara, Antoine
影响因子：
56.9
作者：
Contreras, Marco;Ceric, Francisco;Torrealba, Fernando
通讯作者：
Torrealba, Fernando
DOI：
10.1073/pnas.0808023105
发表时间：
2008-12-09
影响因子：
11.1
作者：
Hollander, Jonathan A.;Lu, Qun;Kenny, Paul J.
通讯作者：
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影响因子：
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作者：
Drouin, C;Waterhouse, BD
通讯作者：
Waterhouse, BD
影响因子：
2.5
作者：
Hoffer, ZS;Alloway, KD
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Alloway, KD