Optimal axonal and dendritic branching strategies during the development of neural circuitry.
Optimal axonal and dendritic branching strategies during the development of neural circuitry.
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DOI：
10.3389/neuro.04.018.2009
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发表时间：
2009
影响因子：
3.5
通讯作者：
Koulakov A
中科院分区：
文献类型：
--
作者：
Tsigankov D;Koulakov A
在大脑发育过程中，轴突和树突能够以很高的精度相互连接。活体轴突和树突动力学成像显示，大多数轴突和树突分支错误地形成，只是后来被收回。分支机构生产过剩的功能意义尚不明确。在这里，我们表明轴突和树突的分支可以在神经元回路的发展过程中加速寻找合适的突触靶点。我们认为，由轴突和树突实施的分支规则最大限度地减少了错误分支的数量。我们发现，轴突和树突的最佳分枝规则不同，这与实验观察到的分枝动力学一致。因此，我们的研究表明，发育中的神经系统采用了一套复杂的计算策略，以最快、最省钱的方式促进了所需电路的形成。
In developing brain, axons and dendrites are capable of connecting to each other with high precision. Imaging of axonal and dendritic dynamics in vivo shows that the majority of axonal and dendritic branches are formed ‘in error’, only to be retracted later. The functional significance of the overproduction of branches is not clear. Here we show that branching of both axons and dendrites can accelerate finding appropriate synaptic targets during the development of neuronal circuitry. We suggest that branching rules implemented by axons and dendrites minimize the number of erroneous branches. We find that optimal branching rules are different for axons and dendrites in agreement with experimentally observed branch dynamics. Thus, our studies suggest that the developing neural system employs a set of sophisticated computational strategies that facilitate the formation of required circuitry in the fastest and most frugal way.
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