Secretome of Mesenchymal Bone Marrow Stem Cells: Is It Immunosuppressive or Proinflammatory?
Secretome of Mesenchymal Bone Marrow Stem Cells: Is It Immunosuppressive or Proinflammatory?
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DOI：
10.1007/s10517-021-05371-5
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发表时间：
2021-12
影响因子：
0.7
通讯作者：
Varfolomeeva SR
中科院分区：
文献类型：
--
作者：
Kiselevskii MV;Vlasenko RY;Stepanyan NG;Shubina IZ;Sitdikova SM;Kirgizov KI;Varfolomeeva SR
间充质干细胞（MSC）的特征在于具有致耐受性潜力，因此，用于治疗自身免疫性疾病，例如异基因造血细胞移植后的移植物抗宿主病（GVHD）反应，以改善移植功能，以及用于治疗和预防COVID-19患者和一些其他病症中的细胞因子风暴。然而，MSC可以表现出促炎活性，这导致其临床使用的风险。我们研究了骨髓MSC培养物的细胞因子谱，并证明IL-6、IL-8和趋化因子MCP-1的大量产生，它们参与细胞因子风暴和GVHD的发病机制。同时，未检测到抗炎性IL-4和IL-10。为了降低MSC在GVHD治疗方案中应用的风险，需要进一步研究促进具有致耐受性潜力的MSC产生的条件和批准的MSC使用的临床标准。
Mesenchymal stem cells (MSC) are characterized by tolerogenic potential and therefore, are used in the treatment of autoimmune diseases such as graft-versus-host disease (GVHD) reactions after allogeneic hematopoietic cell transplantation to improve the transplant functions, as well as for the therapy and prevention of cytokine storm in COVID-19 patients and some other conditions. However, MSC can exhibit proinflammatory activity, which causes risks for their clinical use. We studied the cytokine profile of bone marrow MSC culture and demonstrate intensive production of IL-6, IL-8, and chemokine MCP-1, which participate in the pathogenesis of cytokine storm and GVHD. At the same time, no anti-inflammatory IL-4 and IL-10 were detected. To reduce the risks of MSC application in the GVHD therapeutic protocols, further studies of the conditions promoting generation of MSC with tolerogenic potential and approved clinical standards of MSC use are required.
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影响因子：
4.8
作者：
Gazdic, Marina;Volarevic, Vladislav;Stojkovic, Miodrag
通讯作者：
Stojkovic, Miodrag
DOI：
10.1016/j.bbmt.2011.07.001
发表时间：
2011-12
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Drobyski WR;Pasquini M;Kovatovic K;Palmer J;Douglas Rizzo J;Saad A;Saber W;Hari P
通讯作者：
Hari P
影响因子：
7.5
作者：
Li T;Luo C;Zhang J;Wei L;Sun W;Xie Q;Liu Y;Zhao Y;Xu S;Wang L
通讯作者：
Wang L
影响因子：
6.2
作者：
Siegel, Georg;Schaefer, Richard;Dazzi, Francesco
通讯作者：
Dazzi, Francesco
影响因子：
4
作者：
Pricola, Katie L.;Kuhn, Nastaran Z.;Haleem-Smith, Hana;Song, Yingjie;Tuan, Rocky S.
通讯作者：
Tuan, Rocky S.