Self-reinnervated muscles lose autogenic length feedback, but intermuscular feedback can recover functional connectivity.
Self-reinnervated muscles lose autogenic length feedback, but intermuscular feedback can recover functional connectivity.
复制标题
自我神经重新支配的肌肉失去自生长度反馈，但肌肉间反馈可以恢复功能连接。
DOI：
10.1152/jn.00335.2016
复制
发表时间：
2016
影响因子：
2.5
通讯作者：
Nichols,TRichard
中科院分区：
文献类型：
--
作者：
Lyle,MarkA;Prilutsky,BorisI;Gregor,RobertJ;Abelew,ThomasA;Nichols,TRichard
在这项研究中，我们试图确定感觉回路负责运动缺陷或代偿性适应后，周围神经切断和修复。踝关节伸肌的自我神经支配消除了牵张反射，并增加了下坡行走时的踝关节屈服，但这一发现是否适用于其他肌肉群以及肌肉是否完全失去传入神经仍是未知数。在去大脑猫神经切断和修复后至少19周，我们研究了四头肌（Q）肌肉的自我神经再生对猫后肢主要伸肌之间的自生长度反馈，以及肌间长度和力反馈的影响。腓肠肌和比目鱼肌自我神经再支配肌间回路的影响进行了评价。我们发现，自生长度反馈Q自我神经支配后丢失，这表明牵张反射的损失似乎是肌肉自我神经支配的一个可推广的后果。然而，肌间力和长度反馈，诱发自神经支配的肌肉，被保存在大多数的相互作用，类似的相对抑制或兴奋的幅度进行评估。这些数据表明，肌间脊髓反射回路有能力恢复功能连接，但恢复不是绝对的。解释肌间反馈的恢复进行了讨论，根据确定的机制负责失去自生长度反馈。功能的影响，由于永久性丧失的自生长度反馈和潜在的补偿性适应保存肌间反馈，进行了讨论。
In this study, we sought to identify sensory circuitry responsible for motor deficits or compensatory adaptations after peripheral nerve cut and repair. Self-reinnervation of the ankle extensor muscles abolishes the stretch reflex and increases ankle yielding during downslope walking, but it remains unknown whether this finding generalizes to other muscle groups and whether muscles become completely deafferented. In decerebrate cats at least 19 wk after nerve cut and repair, we examined the influence of quadriceps (Q) muscles' self-reinnervation on autogenic length feedback, as well as intermuscular length and force feedback, among the primary extensor muscles in the cat hindlimb. Effects of gastrocnemius and soleus self-reinnervation on intermuscular circuitry were also evaluated. We found that autogenic length feedback was lost after Q self-reinnervation, indicating that loss of the stretch reflex appears to be a generalizable consequence of muscle self-reinnervation. However, intermuscular force and length feedback, evoked from self-reinnervated muscles, was preserved in most of the interactions evaluated with similar relative inhibitory or excitatory magnitudes. These data indicate that intermuscular spinal reflex circuitry has the ability to regain functional connectivity, but the restoration is not absolute. Explanations for the recovery of intermuscular feedback are discussed, based on identified mechanisms responsible for lost autogenic length feedback. Functional implications, due to permanent loss of autogenic length feedback and potential for compensatory adaptations from preserved intermuscular feedback, are discussed.
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影响因子：
2.2
作者：
English, Arthur W.;Wilhelm, Jennifer C.;Sabatier, Manning J.
通讯作者：
Sabatier, Manning J.
自发运动前乳头猫后肢伸肌之间的异质反馈。
影响因子：
2.5
作者：
Ross,KylaT;Nichols,TRichard
通讯作者：
Nichols,TRichard
一关节和二关节增效肌之间的协调机制
DOI：
--
发表时间：
2016
期刊：
影响因子：
--
作者：
Ricky Mehta
通讯作者：
Ricky Mehta
影响因子：
2.5
作者：
SAINBURG, RL;POIZNER, H;GHEZ, C
通讯作者：
GHEZ, C
影响因子：
2.5
作者：
GORDON, J;GHILARDI, MF;GHEZ, C
通讯作者：
GHEZ, C