Multi sequence average templates for aging and neurodegenerative disease populations.

Multi sequence average templates for aging and neurodegenerative disease populations.
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DOI:
10.1038/s41597-022-01341-2
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发表时间:
2022-05-27
期刊:
影响因子:
9.8
通讯作者:
Duchesne, Simon
Duchesne, Simon
中科院分区:
综合性期刊2区
文献类型:
--
作者:
Dadar, Mahsa;Camicioli, Richard;Duchesne, Simon

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磁共振图像(MRI)处理流水线使用平均模板来实现公共空间中的个体MRI的标准化。MNI-ICBM 152目前被大多数MRI处理工具用作标准模板。然而,MNI-ICBM 152代表了平均152个健康的年轻成人大脑,与神经退行性疾病患者的大脑有很大不同。在这些人群中,当使用年轻健康个体的平均模板进行标准化时,广泛的萎缩可能会导致不可避免的登记错误。代表群体解剖学特征的疾病特异性模板可以减少此类误差并改善下游驱动的估计。我们提出了阿尔茨海默氏痴呆(AD)、额颞叶痴呆(FTD)、路易体痴呆(LBD)、轻度认知障碍(MCI)、认知完整和受损的帕金森氏病患者的多序列平均模板(分别为PD-CIE和PD-CI)、患有主观认知障碍(SCI)、具有血管贡献的AD(V-AD)、血管性轻度认知障碍(V-MCI)的个体,认知完整的老年人(CIE)个体和人类幻影。我们还为男性和女性提供了单独的模板,以便更好地代表每个性别组的疾病。
Magnetic resonance image (MRI) processing pipelines use average templates to enable standardization of individual MRIs in a common space. MNI-ICBM152 is currently used as the standard template by most MRI processing tools. However, MNI-ICBM152 represents an average of 152 healthy young adult brains and is vastly different from brains of patients with neurodegenerative diseases. In those populations, extensive atrophy might cause inevitable registration errors when using an average template of young healthy individuals for standardization. Disease-specific templates that represent the anatomical characteristics of the populations can reduce such errors and improve downstream driven estimates. We present multi-sequence average templates for Alzheimer’s Dementia (AD), Fronto-temporal Dementia (FTD), Lewy Body Dementia (LBD), Mild Cognitive Impairment (MCI), cognitively intact and impaired Parkinson’s Disease patients (PD-CIE and PD-CI, respectively), individuals with Subjective Cognitive Impairment (SCI), AD with vascular contribution (V-AD), Vascular Mild Cognitive Impairment (V-MCI), Cognitively Intact Elderly (CIE) individuals, and a human phantom. We also provide separate templates for males and females to allow better representation of the diseases in each sex group.
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