HMDB 3.0--The Human Metabolome Database in 2013.
HMDB 3.0--The Human Metabolome Database in 2013.
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DOI：
10.1093/nar/gks1065
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发表时间：
2013-01
影响因子：
14.9
通讯作者：
Scalbert A
中科院分区：
文献类型：
--
作者：
Wishart DS;Jewison T;Guo AC;Wilson M;Knox C;Liu Y;Djoumbou Y;Mandal R;Aziat F;Dong E;Bouatra S;Sinelnikov I;Arndt D;Xia J;Liu P;Yallou F;Bjorndahl T;Perez-Pineiro R;Eisner R;Allen F;Neveu V;Greiner R;Scalbert A
人类代谢组数据库（HMDB）（www.hmdb.ca）是一个致力于为科学家提供最新和最全面的人类代谢组覆盖的资源。自2007年首次发布以来，HMDB已被用于促进代谢组学、临床生物化学和系统生物学领域近1000项已发表研究的研究。HMDB的最新版本（3.0版）在2009年版本（2.0版）的基础上进行了显著的扩展和增强。特别是，注释代谢物条目的数量从6500增加到40000多（增加了600%）。这一巨大的扩展是包括“检测到的”代谢物（具有测量浓度或实验确认其存在的代谢物）和“预期的”代谢物（已知生化途径或人体摄入/暴露频繁但尚未在体内检测到化合物的代谢物）的结果。最新版本还大大增加了具有生物流体或组织浓度数据的代谢物数量、具有参考光谱的化合物数量以及每个条目的数据字段数量。除了数据量的增加之外，还增加或增强了新的数据库可视化工具和新的数据内容。这些包括更好的光谱查看工具，更强大的化学亚结构搜索，改进的化学分类和更好的，更具互动性的途径地图。本文描述了对HMDB的这些增强，这在2009年NAR数据库问题中已经有过介绍。(Note HMDB 3.0将于2012年9月18日上线。
The Human Metabolome Database (HMDB) (www.hmdb.ca) is a resource dedicated to providing scientists with the most current and comprehensive coverage of the human metabolome. Since its first release in 2007, the HMDB has been used to facilitate research for nearly 1000 published studies in metabolomics, clinical biochemistry and systems biology. The most recent release of HMDB (version 3.0) has been significantly expanded and enhanced over the 2009 release (version 2.0). In particular, the number of annotated metabolite entries has grown from 6500 to more than 40 000 (a 600% increase). This enormous expansion is a result of the inclusion of both ‘detected’ metabolites (those with measured concentrations or experimental confirmation of their existence) and ‘expected’ metabolites (those for which biochemical pathways are known or human intake/exposure is frequent but the compound has yet to be detected in the body). The latest release also has greatly increased the number of metabolites with biofluid or tissue concentration data, the number of compounds with reference spectra and the number of data fields per entry. In addition to this expansion in data quantity, new database visualization tools and new data content have been added or enhanced. These include better spectral viewing tools, more powerful chemical substructure searches, an improved chemical taxonomy and better, more interactive pathway maps. This article describes these enhancements to the HMDB, which was previously featured in the 2009 NAR Database Issue. (Note to referees, HMDB 3.0 will go live on 18 September 2012.).
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影响因子：
14.9
作者：
Wishart DS;Knox C;Guo AC;Eisner R;Young N;Gautam B;Hau DD;Psychogios N;Dong E;Bouatra S;Mandal R;Sinelnikov I;Xia J;Jia L;Cruz JA;Lim E;Sobsey CA;Shrivastava S;Huang P;Liu P;Fang L;Peng J;Fradette R;Cheng D;Tzur D;Clements M;Lewis A;De Souza A;Zuniga A;Dawe M;Xiong Y;Clive D;Greiner R;Nazyrova A;Shaykhutdinov R;Li L;Vogel HJ;Forsythe I
通讯作者：
Forsythe I
HMDB：人类代谢组数据库。
影响因子：
14.9
作者：
Wishart, David S;Tzur, Dan;Knox, Craig;Eisner, Roman;Guo, An Chi;Young, Nelson;Cheng, Dean;Jewell, Kevin;Arndt, David;Sawhney, Summit;Fung, Chris;Nikolai, Lisa;Lewis, Mike;Coutouly, Marie-Aude;Forsythe, Ian;Tang, Peter;Shrivastava, Savita;Jeroncic, Kevin;Stothard, Paul;Amegbey, Godwin;Block, David;Hau, David D;Wagner, James;Miniaci, Jessica;Clements, Melisa;Gebremedhin, Mulu;Guo, Natalie;Zhang, Ying;Duggan, Gavin E;Macinnis, Glen D;Weljie, Alim M;Dowlatabadi, Reza;Bamforth, Fiona;Clive, Derrick;Greiner, Russ;Li, Liang;Marrie, Tom;Sykes, Brian D;Vogel, Hans J;Querengesser, Lori
通讯作者：
Querengesser, Lori
影响因子：
64.8
作者：
Sreekumar, Arun;Poisson, Laila M.;Rajendiran, Thekkelnaycke M.;Khan, Amjad P.;Cao, Qi;Yu, Jindan;Laxman, Bharathi;Mehra, Rohit;Lonigro, Robert J.;Li, Yong;Nyati, Mukesh K.;Ahsan, Aarif;Kalyana-Sundaram, Shanker;Han, Bo;Cao, Xuhong;Byun, Jaeman;Omenn, Gilbert S.;Ghosh, Debashis;Pennathur, Subramaniam;Alexander, Danny C.;Berger, Alvin;Shuster, Jeffrey R.;Wei, John T.;Varambally, Sooryanarayana;Beecher, Christopher;Chinnaiyan, Arul M.
通讯作者：
Chinnaiyan, Arul M.
影响因子：
14.9
作者：
Kanehisa M;Goto S;Sato Y;Furumichi M;Tanabe M
通讯作者：
Tanabe M
影响因子：
14.9
作者：
Frolkis A;Knox C;Lim E;Jewison T;Law V;Hau DD;Liu P;Gautam B;Ly S;Guo AC;Xia J;Liang Y;Shrivastava S;Wishart DS
通讯作者：
Wishart DS