SMPDB: The Small Molecule Pathway Database.
SMPDB: The Small Molecule Pathway Database.
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DOI：
10.1093/nar/gkp1002
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发表时间：
2010-01
影响因子：
14.9
通讯作者：
Wishart DS
中科院分区：
文献类型：
--
作者：
Frolkis A;Knox C;Lim E;Jewison T;Law V;Hau DD;Liu P;Gautam B;Ly S;Guo AC;Xia J;Liang Y;Shrivastava S;Wishart DS
小分子途径数据库（SMPDB）是一个交互式的可视化数据库，包含350多种在人类中发现的小分子途径。超过2/3的通路（>280）没有在任何其他通路数据库中找到。SMPDB专为支持临床代谢组学、转录组学、蛋白质组学和系统生物学中的途径阐明和途径发现而设计。SMPDB提供了人类代谢途径、代谢性疾病途径、代谢物信号通路和药物作用途径的精细详细的超链接图表。所有SMPDB通路包括相关器官、细胞器、亚细胞区室、蛋白质辅因子、蛋白质位置、代谢物位置、化学结构和蛋白质四级结构的信息。每个小分子都与人类代谢组数据库（HMDB）或DrugBank中包含的详细描述超链接，每个蛋白质或酶复合物都与UniProt超链接。所有SMPDB通路都附有详细描述，提供每个图中描述的通路、条件或过程的概述。该数据库易于浏览，并支持全文搜索。用户可以使用代谢物名称、药物名称、基因/蛋白质名称、SwissProt id、GenBank id、Affymetrix id或Agilent微阵列id列表查询SMPDB。这些查询将产生匹配途径的列表，并在每个途径图上突出显示匹配的分子。基因、代谢物和蛋白质浓度数据也可以通过SMPDB的映射界面可视化。SMPDB的所有图像、图像映射、描述和表格都可以下载。SMPDB可从http://www.smpdb.ca获取。
The Small Molecule Pathway Database (SMPDB) is an interactive, visual database containing more than 350 small-molecule pathways found in humans. More than 2/3 of these pathways (>280) are not found in any other pathway database. SMPDB is designed specifically to support pathway elucidation and pathway discovery in clinical metabolomics, transcriptomics, proteomics and systems biology. SMPDB provides exquisitely detailed, hyperlinked diagrams of human metabolic pathways, metabolic disease pathways, metabolite signaling pathways and drug-action pathways. All SMPDB pathways include information on the relevant organs, organelles, subcellular compartments, protein cofactors, protein locations, metabolite locations, chemical structures and protein quaternary structures. Each small molecule is hyperlinked to detailed descriptions contained in the Human Metabolome Database (HMDB) or DrugBank and each protein or enzyme complex is hyperlinked to UniProt. All SMPDB pathways are accompanied with detailed descriptions, providing an overview of the pathway, condition or processes depicted in each diagram. The database is easily browsed and supports full text searching. Users may query SMPDB with lists of metabolite names, drug names, genes/protein names, SwissProt IDs, GenBank IDs, Affymetrix IDs or Agilent microarray IDs. These queries will produce lists of matching pathways and highlight the matching molecules on each of the pathway diagrams. Gene, metabolite and protein concentration data can also be visualized through SMPDB’s mapping interface. All of SMPDB’s images, image maps, descriptions and tables are downloadable. SMPDB is available at: http://www.smpdb.ca.
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影响因子：
14.9
作者：
Wishart, David S;Tzur, Dan;Knox, Craig;Eisner, Roman;Guo, An Chi;Young, Nelson;Cheng, Dean;Jewell, Kevin;Arndt, David;Sawhney, Summit;Fung, Chris;Nikolai, Lisa;Lewis, Mike;Coutouly, Marie-Aude;Forsythe, Ian;Tang, Peter;Shrivastava, Savita;Jeroncic, Kevin;Stothard, Paul;Amegbey, Godwin;Block, David;Hau, David D;Wagner, James;Miniaci, Jessica;Clements, Melisa;Gebremedhin, Mulu;Guo, Natalie;Zhang, Ying;Duggan, Gavin E;Macinnis, Glen D;Weljie, Alim M;Dowlatabadi, Reza;Bamforth, Fiona;Clive, Derrick;Greiner, Russ;Li, Liang;Marrie, Tom;Sykes, Brian D;Vogel, Hans J;Querengesser, Lori
通讯作者：
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影响因子：
14.9
作者：
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通讯作者：
UniProt Consortium
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影响因子：
9.9
作者：
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通讯作者：
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影响因子：
14.9
作者：
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影响因子：
14.9
作者：
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通讯作者：
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