Adaptation of experimental yeast populations to stressful conditions in relation to population size
Adaptation of experimental yeast populations to stressful conditions in relation to population size
复制标题
实验酵母种群对与种群规模相关的应激条件的适应
DOI：
10.1111/j.1420-9101.2010.01945.x
复制
发表时间：
2010
影响因子：
2.1
通讯作者：
G. Bell
中科院分区：
文献类型：
--
作者：
P. Samani;G. Bell
这个实验的目的是为了找出当环境恶化时，一个种群是如何适应极端压力条件的。我们通过逐步增加生长培养基中的盐浓度，为酵母的实验选择系创造了一个恶化的环境。在每一步之后，我们测试了这些品系在接近祖先菌株致死极限的高浓度盐下生长的能力。我们发现，在这种高压力环境中促进生长的突变在中等盐浓度下开始传播。增强程度与有效种群大小呈幂函数关系，指数较小。这些突变的效应大小也以类似的方式随着群体大小而增加。从这些结果中，我们解释适应致命的压力作为一个间接的反应，选择以前的较低水平的压力在恶化的环境。这表明，压力水平不断提高之间的遗传相关性模式是促进进化拯救的一个重要因素。
The purpose of this experiment was to find out how a population becomes adapted to extremely stressful conditions as its environment deteriorates. We created a deteriorating environment for experimental selection lines of yeast by a stepwise increase in the concentration of salt in the growth medium. After each step, we tested the ability of the lines to grow at a high concentration of salt near the lethal limit for the ancestral strain. We found that mutations enhancing growth in this highly stressful environment began to spread at intermediate salt concentrations. The degree of enhancement was related to effective population size by a power law with a small exponent. The effect size of these mutations also increased with the population size in a similar fashion. From these results, we interpret adaptation to lethal stress as an indirect response to selection for resistance to previous lower levels of stress in a deteriorating environment. This suggests that the pattern of genetic correlation between successively higher levels of stress is an important factor in facilitating evolutionary rescue.
影响因子：
3.3
作者：
Weber,KE;Diggins,LT
通讯作者：
Diggins,LT
影响因子：
3.3
作者：
Weber,KE
通讯作者：
Weber,KE
影响因子：
3.3
作者：
Lang, Gregory I.;Murray, Andrew W.
通讯作者：
Murray, Andrew W.