Genome-wide association study of pancreatic cancer in Japanese population.
Genome-wide association study of pancreatic cancer in Japanese population.
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DOI：
10.1371/journal.pone.0011824
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发表时间：
2010-07-29
期刊：
影响因子：
3.7
通讯作者：
Sakamoto H
中科院分区：
文献类型：
--
作者：
Low SK;Kuchiba A;Zembutsu H;Saito A;Takahashi A;Kubo M;Daigo Y;Kamatani N;Chiku S;Totsuka H;Ohnami S;Hirose H;Shimada K;Okusaka T;Yoshida T;Nakamura Y;Sakamoto H
胰腺癌显示出非常糟糕的预后，是日本癌症死亡的第五大原因。以前的研究表明，一些遗传因素与胰腺癌的发生和发展有关；然而，关于常见的基因变异与这种疾病有关的报道有限，特别是在亚洲人群中。我们对991例浸润性胰腺导管腺癌和5,209例对照进行了全基因组关联研究，发现3个基因座(P值和lt；5×10−，7)与胰腺癌的易感性显著相关。存在显著关联的SNP的优势比分别为1.29、1.32和3.73，95%可信区间分别为1.17~1.43、1.19~1.47和2.24~6.21，P值分别为3.30×10−7、3.30×10−7和4.41×10−7，分别位于染色体6p25.3、12p11.21和7q36.2上。这些相关的SNPs位于连锁不平衡块中，包含与胰腺癌发生有关的基因。
Pancreatic cancer shows very poor prognosis and is the fifth leading cause of cancer death in Japan. Previous studies indicated some genetic factors contributing to the development and progression of pancreatic cancer; however, there are limited reports for common genetic variants to be associated with this disease, especially in the Asian population. We have conducted a genome-wide association study (GWAS) using 991 invasive pancreatic ductal adenocarcinoma cases and 5,209 controls, and identified three loci showing significant association (P-value<5×10−7) with susceptibility to pancreatic cancer. The SNPs that showed significant association carried estimated odds ratios of 1.29, 1.32, and 3.73 with 95% confidence intervals of 1.17–1.43, 1.19–1.47, and 2.24–6.21; P-value of 3.30×10−7, 3.30×10−7, and 4.41×10−7; located on chromosomes 6p25.3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer.
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影响因子：
2.9
作者：
B端chler, P;Conejo-Garcia, JR;Friess, H
通讯作者：
Friess, H
影响因子：
6.4
作者：
BERROZPE, G;SCHAEFFER, J;PERUCHO, M
通讯作者：
PERUCHO, M
影响因子：
4.5
作者：
Gatbonton T;Imbesi M;Nelson M;Akey JM;Ruderfer DM;Kruglyak L;Simon JA;Bedalov A
通讯作者：
Bedalov A
DOI：
10.1126/science.1171202
发表时间：
2009-04-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jones S;Hruban RH;Kamiyama M;Borges M;Zhang X;Parsons DW;Lin JC;Palmisano E;Brune K;Jaffee EM;Iacobuzio-Donahue CA;Maitra A;Parmigiani G;Kern SE;Velculescu VE;Kinzler KW;Vogelstein B;Eshleman JR;Goggins M;Klein AP
通讯作者：
Klein AP
影响因子：
10.3
作者：
Hahn, SA;Greenhalf, B;Bartsch, DK
通讯作者：
Bartsch, DK