Maternal Serum α-Fetoprotein Levels during Pregnancy and Testicular Cancer in Male Offspring: A Cohort Study within a Danish Pregnancy Screening Registry.
Maternal Serum α-Fetoprotein Levels during Pregnancy and Testicular Cancer in Male Offspring: A Cohort Study within a Danish Pregnancy Screening Registry.
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DOI：
10.3390/ijerph192114112
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发表时间：
2022-10-28
影响因子：
--
通讯作者：
Brauner, Elvira, V
中科院分区：
文献类型：
--
作者：
Uldbjerg, Cecilie S.;Lim, Youn-Hee;Glazer, Clara H.;Hauser, Russ;Juul, Anders;Brauner, Elvira, V
睾丸癌被认为起源于子宫内正常雄激素-雌激素平衡的破坏。甲胎蛋白（AFP）可通过雌激素相互作用改变胎儿对雌激素的反应。在一项队列研究中，我们调查了循环母体妊娠AFP和后代睾丸癌风险之间的关系。在1980-1995年妊娠筛查登记的56，709例活产男性中，我们的研究包括50，519例单胎男性，他们的母亲提供了中期妊娠血液样本，并完成了协变量确定。睾丸癌诊断和协变量数据来自丹麦全国健康登记处。考克斯回归和Kaplan-Meier分析通过AFP中位数的倍数来估计睾丸癌的前瞻性风险（所有，睾丸癌，非睾丸癌）。在随访期间，163例（0.3%）男性发生睾丸癌，其中89例（54.6%）为非睾丸癌。与AFP低于中位数相比，母亲血清AFP水平大于/等于中位数与睾丸癌的相对风险接近1（RR 1.04，95%CI 0.76; 1.41）相关。睾丸癌类型的相关性不同（RR睾丸癌0.81，95% CI 0.51; 1.29，RR非睾丸癌1.31，95% CI 0.85; 2.02）。总的来说，我们的研究结果并不支持妊娠期血清AFP可以作为后代睾丸癌的预测因子。
Testicular cancer is believed to originate from disruptions of normal androgen-estrogen balance in-utero. α-fetoprotein (AFP) may modify fetal response to estrogens via estrogen interaction. In a cohort study, we investigated the association between circulating maternal pregnancy AFP and testicular cancer risk in offspring. Of the 56,709 live-born males from a pregnancy screening registry in 1980–1995, our study included 50,519 singleton males with available second trimester blood samples from their mothers and complete covariate ascertainment. Testicular cancer diagnoses and covariate data were obtained from nationwide Danish health registries. Cox regression and Kaplan–Meier analyses estimated the prospective risk of testicular cancer (all, seminoma, nonseminoma) by AFP multiples of the median. During follow-up, 163 (0.3%) of the included males developed testicular cancer, of which 89 (54.6%) were nonseminomas. Maternal serum AFP levels greater than/equal to the median were associated with a relative risk of testicular cancer close to unity (RR 1.04, 95% CI 0.76; 1.41) compared to AFP below the median. Associations differed by type of testicular cancer (RRseminoma 0.81, 95% CI 0.51; 1.29, RRnonseminoma 1.31, 95% CI 0.85; 2.02). On balance, our findings do not support that serum AFP in pregnancy can be used as a predictor of testicular cancer in offspring.
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