Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats.
Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats.
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DOI：
10.1016/j.cardfail.2011.08.006
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发表时间：
2011-12
影响因子：
6
通讯作者：
Kang, Peter M.
中科院分区：
文献类型：
--
作者：
Choi, Jun H.;Ke, Qingen;Bae, Soochan;Lee, Ji Yoo;Kim, Yu Jin;Kim, Ui Kyoung;Arbeeny, Cynthia;Thadhani, Ravi;Kang, Peter M.
激活的维生素D类似物，Paricalitol，已被证明可以减缓Dahl盐敏感型(DSS)大鼠心肌肥厚的发展。为了确定抗肥厚作用是否具有类别特异性，我们测试了多沙钙化醇(一种激素前体维生素D2类似物)是否也可以减缓DSS大鼠心肌肥厚的发展。雄性DSS大鼠从6周龄开始饲喂高盐饲料6周。多索钙化醇腹腔注射(i.p)。150 ng，每周3次(周一、周三、周五)，共6周。病理和超声心动图结果显示，与HS+赋形剂相比，服用HS饲料加多索钙化醇的大鼠心肌肥厚明显减少，心功能得到改善。多虑钙治疗后，血浆脑利钠肽(BNP)水平和组织心钠素(ANF)mRNA水平均显著降低。Doxercalferol还显着降低蛋白激酶C-α(PKCα)水平，提示PKC介导的心肌肥大可能与维生素D缺乏有关。多索钙化醇可减轻HS饮食诱导的DSS大鼠心肌肥厚和心功能不全。
Activated vitamin D analog, paricalcitol, has been shown to attenuate the development of cardiac hypertrophy in Dahl salt sensitive (DSS) rats. To determine whether an anti-hypertrophic effect is class specific, we tested if doxercalciferol (a pro-hormone vitamin D2 analog) could also attenuate the development of cardiac hypertrophy in DSS rats. Male DSS rats were fed a high salt (HS) diet for 6 weeks beginning at 6 weeks of age. Doxercalciferol was administered intraperitoneally (i.p.) at 150ng, 3 times a week (Mon, Wed, Fri) for six weeks. Pathological and echocardiographic findings demonstrated that rats on HS diet with doxercalciferol administration had significant decrease in cardiac hypertrophy and improved cardiac function compared to the HS + vehicle. In addition, there was a significant decrease in plasma brain natriuretic peptide (BNP) level and tissue atrial natriuretic factor (ANF) mRNA level with doxercalciferol treatment. Doxercalciferol also significantly reduced the level of protein kinase C-α (PKCα) suggesting that PKC-mediated cardiac hypertrophy may be associated with vitamin D deficiency. Administration of doxercalciferol attenuated the development of HS diet induced cardiac hypertrophy and cardiac dysfunction in DSS rats.
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影响因子：
5.4
作者：
Koide, Y;Tamura, K;Umemura, S
通讯作者：
Umemura, S
影响因子：
8.3
作者：
Chen, SC;Wu, JM;Gardner, DG
通讯作者：
Gardner, DG
DOI：
10.1152/ajpheart.00562.2008
发表时间：
2009-03-01
影响因子：
4.8
作者：
Rigor, Debra L.;Bodyak, Natalya;Kang, Peter M.
通讯作者：
Kang, Peter M.
影响因子：
13.6
作者：
Teng, M;Wolf, M;Thadhani, R
通讯作者：
Thadhani, R
影响因子：
4.3
作者：
Sabri, A;Steinberg, SF
通讯作者：
Steinberg, SF