Differentiation of cerebral representation of occlusion and swallowing with fMRI.
Differentiation of cerebral representation of occlusion and swallowing with fMRI.
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功能磁共振成像 (fMRI) 区分闭塞和吞咽的大脑表征
DOI：
10.1152/ajpgi.00456.2012
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Lotze M.
中科院分区：
文献类型：
--
作者：
Mihai PG;von Bohlen;Halbach O;Lotze M.
关于表征特异性的早期研究和颞下颌关节 (TMJ) 运动表征的最新发现引起了人们对特定吞咽表征是否存在的怀疑。此外，在皮质刺激期间，颞下颌关节运动和吞咽显示出初级运动皮质中代表性区域的高度重叠。因此，人们假设它们总体上可能共享相同的神经结构。为了区分这两种动作，我们进行了功能性 MRI (fMRI) 研究，可以直接比较同一受试者组中两种动作的功能表征。这些任务期间的努力是由皮肤电导反应控制的。在平衡努力时，我们发现这两项任务的神经表征模式具有可比性，但在任务之间的直接比较中执行吞咽所需的资源有所增加。我们首次利用功能磁共振成像（fMRI）展示了脑干中吞咽和闭塞的表征。在双侧感觉运动皮层、双侧前运动皮层和辅助运动皮层、运动扣带皮层、丘脑、小脑半球、左侧苍白球、双侧脑桥和中脑中观察到吞咽激活增加。两种条件下初级运动皮层的激活峰值大约相距 5 毫米。发现脑干激活对应于三叉神经的感觉核、吞咽的孤核和闭塞的三叉神经核。我们的数据表明，闭塞和吞咽的大脑表征在空间上广泛重叠，主要在所涉及的神经资源数量方面有所不同。脑干和初级运动表征在体位和脑神经核的贡献方面的位置不同。
Early work on representational specificity and recent findings on temporomandibular joint (TMJ) movement representation raise doubts that a specific swallow representation does exist. Additionally, during cortical stimulation TMJ movements and swallowing show a high overlap of representational areas in the primary motor cortex. It has thus been hypothesized that they overall might share the same neural structures. To differentiate these two movements, we performed a functional MRI (fMRI) study that enabled a direct comparison of functional representation of both actions in the same subject group. Effort during these tasks was controlled by skin conductance response. When balancing effort, we found a comparable neural representation pattern for both tasks but increased resources necessary to perform swallowing in direct comparison between tasks. For the first time, with the usage of fMRI, we demonstrated a representation in the brainstem for swallowing and occlusion. Increased activation for swallowing was observed in bilateral sensorimotor cortex, bilateral premotor and supplementary motor cortex, motor cingulate, thalamus, cerebellar hemispheres, left pallidum, bilateral pons, and midbrain. Peaks of activation in primary motor cortex between both conditions were about 5 mm adjacent. Brainstem activation was found corresponding to the sensory nucleus of the trigeminal nerve, the solitary nucleus for swallowing, and the trigeminal nucleus for occlusion. Our data suggest that cerebral representation of occlusion and swallowing are spatially widely overlapping, differing predominantly with respect to the quantity of neural resources involved. Both brainstem and primary motor representation differ in location with respect to somatotopy and contribution of cranial nerve nuclei.
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影响因子：
2
作者：
Mosier, K;Bereznaya, I
通讯作者：
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DOI：
--
发表时间：
1972
期刊：
Journal of Physiology
影响因子：
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L. Tieffenbach;C. Roman
通讯作者：
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影响因子：
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作者：
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影响因子：
2.4
作者：
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