Correlation of intestinal microbiota with overweight and obesity in Kazakh school children.
Correlation of intestinal microbiota with overweight and obesity in Kazakh school children.
复制标题
哈萨克学童肠道菌群与超重和肥胖的相关性
DOI：
10.1186/1471-2180-12-283
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发表时间：
2012-11-28
期刊：
影响因子：
4.2
通讯作者：
Zhang T
中科院分区：
文献类型：
--
作者：
Xu P;Li M;Zhang J;Zhang T
这项研究试图调查7-13岁哈萨克学龄儿童(n = 175)肠道微生物区系、类杆菌和细菌与肥胖之间的可能相关性。与正常和超重参与者相比，肥胖者的收缩压、腰围和臀围以及HOMA-IR显著更高。此外，肥胖组的类杆菌拷贝数和细菌/公司比率显著低于正常组和超重组(P <； 0.0167)。这种差异只在女孩中显著，但在男孩中并不显著，如果按性别分层的话。此外，体重指数与拟杆菌拷贝数(r = −0.18，P = 0.017)以及细菌/公司(r = −0.22，P = 0.003)呈负相关。在哈萨克族女儿童中，肠道类杆菌减少和细菌/公司比率与肥胖之间存在关联。需要进一步的研究来阐明这些变化背后的机制，以及确定它们是否存在对预测肥胖的价值。
This study sought to investigate a possible correlation between the intestinal microbiota, Bacteroidetes and Firmicutes, and obesity in Kazakh school children, aged 7–13 (n = 175). Obese subjects had significantly greater systolic blood pressure, waist and hip circumference, as well as HOMA-IR as compared to normal and overweight participants. In addition, Bacteroides copy number and Bact/Firm ratios were significantly lower in the obese group as compared to the normal and overweight groups (P < 0.0167). This difference is only significant in girls, but not in boys when stratified by gender. Furthermore, a negative correlation between BMI and Bacteroidetes copy number (r = −0.18, P = 0.017) as well as Bact/Firm (r = −0.22, P = 0.003) was observed. An association between reduced gut Bacteroidetes and Bact/Firm ratio with obesity in female Kazakh children was identified. Further studies are necessary to elucidate the mechanism behind these changes as well as the value of determining their presence for predicting obesity.
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DOI：
10.1038/oby.2005.239
发表时间：
2005-11-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Salmon, J;Timperio, A;Crawford, D
通讯作者：
Crawford, D
DOI：
10.1073/pnas.0504978102
发表时间：
2005-08-02
影响因子：
11.1
作者：
Ley, RE;Bäckhed, F;Gordon, JI
通讯作者：
Gordon, JI
影响因子：
10.4
作者：
Snedeker SM;Hay AG
通讯作者：
Hay AG
影响因子：
4.9
作者：
Davison, KK;Birch, LL
通讯作者：
Birch, LL
影响因子：
16.2
作者：
Haffner, SM;Gonzalez, C;Stern, MP
通讯作者：
Stern, MP