Do interactions between gut ecology and environmental chemicals contribute to obesity and diabetes?
Do interactions between gut ecology and environmental chemicals contribute to obesity and diabetes?
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DOI：
10.1289/ehp.1104204
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发表时间：
2012-03
影响因子：
10.4
通讯作者：
Hay AG
中科院分区：
文献类型：
--
作者：
Snedeker SM;Hay AG
工作背景：肠道微生物群是肥胖和糖尿病的重要因素，但对它们在环境化学品（包括最近发现的致肥胖和致糖尿病化学品）的毒理动力学中的作用知之甚少。目的：我们整合了将肠道生态学和环境化学物质与肥胖和糖尿病独立联系起来的证据，为建议这些环境因素如何与这些疾病相互作用提供了一个框架，并确定了未来的研究需求。研究方法：我们检查了无菌或驱虫实验动物的研究，以及评估饮食影响和微生物变化如何影响肥胖和糖尿病的人类研究。总结了评估环境化学品暴露如何影响肥胖和糖尿病的研究的优点和缺点，并确定了肠道生态如何影响环境化学品处置的研究差距。越来越多的证据表明，肠道微生物群组成会影响肥胖和糖尿病，暴露于环境化学物质也是如此。毒理学和药理学文献还表明，肠道微生物群的个体间差异可能会通过以下方式影响化学代谢：化学物质的直接激活、生物转化所需代谢物的消耗、宿主生物转化酶活性的改变、肠肝循环的变化、环境化学物质和/或食物中抗氧化剂的生物利用度的改变以及肠道运动和屏障功能的改变。结论：肠道微生物群的变化可能会影响人体毒理动力学，并增加个体对致肥胖和致糖尿病化学品的暴露。对抗全球肥胖症和糖尿病流行需要多方面的方法，其中应包括更加重视了解和控制个体间肠道微生物变异对人类环境化学品处置的影响。
Background: Gut microbiota are important factors in obesity and diabetes, yet little is known about their role in the toxicodynamics of environmental chemicals, including those recently found to be obesogenic and diabetogenic. Objectives: We integrated evidence that independently links gut ecology and environmental chemicals to obesity and diabetes, providing a framework for suggesting how these environmental factors may interact with these diseases, and identified future research needs. Methods: We examined studies with germ-free or antibiotic-treated laboratory animals, and human studies that evaluated how dietary influences and microbial changes affected obesity and diabetes. Strengths and weaknesses of studies evaluating how environmental chemical exposures may affect obesity and diabetes were summarized, and research gaps on how gut ecology may affect the disposition of environmental chemicals were identified. Results: Mounting evidence indicates that gut microbiota composition affects obesity and diabetes, as does exposure to environmental chemicals. The toxicology and pharmacology literature also suggests that interindividual variations in gut microbiota may affect chemical metabolism via direct activation of chemicals, depletion of metabolites needed for biotransformation, alteration of host biotransformation enzyme activities, changes in enterohepatic circulation, altered bioavailability of environmental chemicals and/or antioxidants from food, and alterations in gut motility and barrier function. Conclusions: Variations in gut microbiota are likely to affect human toxicodynamics and increase individual exposure to obesogenic and diabetogenic chemicals. Combating the global obesity and diabetes epidemics requires a multifaceted approach that should include greater emphasis on understanding and controlling the impact of interindividual gut microbe variability on the disposition of environmental chemicals in humans.
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影响因子：
3.7
作者：
Armougom F;Henry M;Vialettes B;Raccah D;Raoult D
通讯作者：
Raoult D
影响因子：
10.4
作者：
Cox S;Niskar AS;Narayan KM;Marcus M
通讯作者：
Marcus M
影响因子：
8.3
作者：
Coronado-Gonzalez, Jose Antonio;Del Razo, Luz Maria;la Pena, Jorge Escobedo-de
通讯作者：
la Pena, Jorge Escobedo-de
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
定植引起的宿主微生物代谢相互作用。
影响因子：
6.4
作者：
Claus SP;Ellero SL;Berger B;Krause L;Bruttin A;Molina J;Paris A;Want EJ;de Waziers I;Cloarec O;Richards SE;Wang Y;Dumas ME;Ross A;Rezzi S;Kochhar S;Van Bladeren P;Lindon JC;Holmes E;Nicholson JK
通讯作者：
Nicholson JK