Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism.
Changes of Structural and Functional Attention Control Networks in Subclinical Hypothyroidism.
复制标题
亚临床甲状腺功能减退症结构和功能注意控制网络的变化
DOI：
10.3389/fnbeh.2021.725908
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发表时间：
2021
影响因子：
3
通讯作者：
Ma S
中科院分区：
文献类型：
--
作者：
Yin J;Xie L;Luo D;Huang J;Guo R;Zheng Y;Xu W;Duan S;Lin Z;Ma S
**目的**：本研究旨在运用基于体素的形态ometry（VBM）技术探究亚临床甲状腺功能减退症（SCH）患者的脑结构变化，并通过功能性磁共振成像（fMRI）研究患者在执行改良汉字Stroop任务时注意力控制网络的改变。
**方法**：对18例SCH患者和18例匹配的对照受试者进行高分辨率三维（3D）T1加权成像和fMRI扫描。采用蒙特利尔认知评估中文版修订版（MoCA - CR）和Stroop任务评估参与者的认知和注意力控制能力。
**结果**：与对照组相比，VBM结果显示SCH患者双侧前额叶皮质（PFC，包括额中回、额内侧回和额下回）、扣带回、楔前叶、左侧颞中回和脑岛的灰质体积（GMV）减少。fMRI结果显示两组均存在一个分布式的脑区网络，包括PFC（包括额上、额中和额下皮质）、前扣带回皮质（ACC）、后扣带回皮质、楔前叶，以及脑岛和尾状核。与对照组相比，SCH组上述脑区的激活程度较低，尤其是在颜色命名任务期间。此外，标准化灰质体积（nGMV）与促甲状腺激素（TSH）水平呈负相关（r = -0.722，p < 0.001）。
**结论**：研究结果表明，SCH患者存在GMV减少、血氧水平依赖（BOLD）信号改变以及与注意力控制相关脑区的激活改变，这进一步提示SCH患者可能存在注意力控制缺陷，而PFC - ACC - 楔前叶脑网络的减弱可能是其神经机制之一。nGMV与TSH之间的负相关表明，TSH升高可能导致大脑皮质出现异常。
Objective: This study aimed to explore the structural changes in patients with subclinical hypothyroidism (SCH) using voxel-based morphometry (VBM) and to investigate the altered attentional control networks using functional MRI (fMRI) during the performance of a modified Stroop task with Chinese characters. Methods: High-resolution three-dimensional (3D) T1-weighted images and an fMRI scan were taken from 18 patients with SCH and 18 matched control subjects. The Montreal Cognitive Assessment Chinese-revised (MoCA-CR) and the Stroop task were used to evaluate the cognitive and attention control of the participants. Results: Compared to controls, the VBM results showed decreased gray matter volumes (GMVs) in bilateral prefrontal cortices (PFCs, including middle, medial, and inferior frontal gyri), cingulate gyrus, precuneus, left middle temporal gyrus, and insula in patients with SCH. The fMRI results showed a distributed network of brain regions in both groups, consisting of PFCs (including superior and middle and inferior frontal cortices), anterior cingulate cortex (ACC), posterior cingulate cortex, and precuneus, as well as the insula and caudate nucleus. Compared to controls, the SCH group had lower activation of the above brain areas, especially during the color-naming task. In addition, the normalized GMV (nGMV) was negatively correlated with thyroid-stimulating hormone (TSH) level (r = −0.722, p < 0.001). Conclusion: Results indicate that patients with SCH exhibit reduced GMVs, altered BOLD signals, and activation in regions associated with attention control, which further suggest that patients with SCH may have attentional control deficiency, and the weakened PFC–ACC–precuneus brain network might be one of the neural mechanisms. Negative correlations between nGMV and TSH suggest that TSH elevation may induce abnormalities in the cortex.
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DOI：
10.1093/cercor/bhp289
发表时间：
2010-09
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Blaizot X;Mansilla F;Insausti AM;Constans JM;Salinas-Alamán A;Pró-Sistiaga P;Mohedano-Moriano A;Insausti R
通讯作者：
Insausti R
影响因子：
3.2
作者：
Herd, SA;Banich, MT;O'Reilly, RC
通讯作者：
O'Reilly, RC
影响因子：
3.7
作者：
Quinque, Eva M.;Karger, Stefan;Villringer, Arno
通讯作者：
Villringer, Arno
影响因子：
5.8
作者：
Pasqualetti, Giuseppe;Pagano, Gennaro;Monzani, Fabio
通讯作者：
Monzani, Fabio
影响因子：
3.7
作者：
Leung, HC;Skudlarski, P;Gore, JC
通讯作者：
Gore, JC