The human parahippocampal region: I. Temporal pole cytoarchitectonic and MRI correlation.
The human parahippocampal region: I. Temporal pole cytoarchitectonic and MRI correlation.
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DOI：
10.1093/cercor/bhp289
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Insausti R
中科院分区：
文献类型：
--
作者：
Blaizot X;Mansilla F;Insausti AM;Constans JM;Salinas-Alamán A;Pró-Sistiaga P;Mohedano-Moriano A;Insausti R
颞极（Temporal pole，TP）是人类颞叶的最靠近喙的部分。其特征是，它只存在于人类和非人类灵长类动物中。TP已经涉及不同的认知功能，如情绪，注意力，行为和记忆，基于在健康对照和神经退行性疾病患者中进行的功能研究，通过其解剖学连接（杏仁核，枕，眶额皮质）。TP最初被Brodmann区域38和von Economo（von Economo和Koskinas的TG区域）描述为单一均匀区域，并且关于其细胞结构的信息在人类中知之甚少。我们假设：1）TP不是一个均匀的区域，我们的目标首先是固定颞极皮层（TPC）与相邻区域的精确范围和界限，2）其结构可以与结构磁共振图像相关。我们在这里描述的宏观特征和细胞结构的两个子域，内侧和外侧区域，构成TPC也值得注意的二维和三维重建。我们的研究结果表明，人类TP是一个异质性区域形成的TPC约7毫米的颞尖，并逐步限制到内侧和腹侧的TP。这个皮质区域呈现出与非人类灵长类动物相同的地形和结构特征，这表明人类物种的进化发展。
The temporal pole (TP) is the rostralmost portion of the human temporal lobe. Characteristically, it is only present in human and nonhuman primates. TP has been implicated in different cognitive functions such as emotion, attention, behavior, and memory, based on functional studies performed in healthy controls and patients with neurodegenerative diseases through its anatomical connections (amygdala, pulvinar, orbitofrontal cortex). TP was originally described as a single uniform area by Brodmann area 38, and von Economo (area TG of von Economo and Koskinas), and little information on its cytoarchitectonics is known in humans. We hypothesize that 1) TP is not a homogenous area and we aim first at fixating the precise extent and limits of temporopolar cortex (TPC) with adjacent fields and 2) its structure can be correlated with structural magnetic resonance images. We describe here the macroscopic characteristics and cytoarchitecture as two subfields, a medial and a lateral area, that constitute TPC also noticeable in 2D and 3D reconstructions. Our findings suggest that the human TP is a heterogeneous region formed exclusively by TPC for about 7 mm of the temporal tip, and that becomes progressively restricted to the medial and ventral sides of the TP. This cortical area presents topographical and structural features in common with nonhuman primates, which suggests an evolutionary development in human species.
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