Heritability of dietary food intake patterns.
Heritability of dietary food intake patterns.
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DOI：
10.1007/s00592-012-0387-0
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发表时间：
2013-10
影响因子：
3.8
通讯作者：
Janssens, A. Cecile J. W.
中科院分区：
文献类型：
--
作者：
van den Berg, Linda;Henneman, Peter;van Dijk, Ko Willems;Delemarre-van de Waal, Henriette A.;Oostra, Ben A.;van Duijn, Cornelia M.;Janssens, A. Cecile J. W.
食物摄入的质量和数量会影响体重，但人们对这种人类饮食摄入模式的遗传学与BMI遗传学的关系知之甚少。我们的目的是估计饮食摄入模式的遗传力和遗传相关性与体重指数的伊拉斯谟鲁克芬家庭研究的参与者。该研究包括1,690名个体（42%男性;年龄范围19-92岁），其中41. 4%超重，15. 9%肥胖。自我报告问卷被用来评估参与者食用蔬菜、水果、果汁、鱼、不健康零食、快餐和软饮料的天数（0-7天）。主成分分析被用来检查问卷项目之间的相关性，并产生饮食摄入模式得分。遗传力和共享的遗传和共享的非遗传（环境）的相关性进行了估计使用的队列的家庭结构。主成分分析表明，问卷项目可以分为健康和不健康的饮食摄入模式，分别解释22%和18%的表型方差。膳食摄入模式的遗传度为0.32的健康和0.27的不健康的模式。膳食摄入模式与BMI之间的遗传相关性不显著，但我们发现不健康的膳食摄入模式与BMI之间存在显著的环境相关性。特定的饮食摄入模式与肥胖的风险有关，并且是可遗传的特征。决定特定饮食摄入模式的遗传因素与决定BMI的遗传因素没有显著重叠。本文的在线版本（doi：10.1007/s 00592 -012-0387-0）包含补充材料，可供授权用户使用。
The quality and quantity of food intake affect body weight, but little is known about the genetics of such human dietary intake patterns in relation to the genetics of BMI. We aimed to estimate the heritability of dietary intake patterns and genetic correlation with BMI in participants of the Erasmus Rucphen Family study. The study included 1,690 individuals (42 % men; age range, 19–92), of whom 41.4 % were overweight and 15.9 % were obese. Self-report questionnaires were used to assess the number of days (0–7) on which participants consumed vegetables, fruit, fruit juice, fish, unhealthy snacks, fastfood, and soft drinks. Principal component analysis was applied to examine the correlations between the questionnaire items and to generate dietary intake pattern scores. Heritability and the shared genetic and shared non-genetic (environmental) correlations were estimated using the family structure of the cohort. Principal component analysis suggested that the questionnaire items could be grouped in a healthy and unhealthy dietary intake pattern, explaining 22 and 18 % of the phenotypic variance, respectively. The dietary intake patterns had a heritability of 0.32 for the healthy and 0.27 for the unhealthy pattern. Genetic correlations between the dietary intake patterns and BMI were not significant, but we found a significant environmental correlation between the unhealthy dietary intake pattern and BMI. Specific dietary intake patterns are associated with the risk of obesity and are heritable traits. The genetic factors that determine specific dietary intake patterns do not significantly overlap with the genetic factors that determine BMI. The online version of this article (doi:10.1007/s00592-012-0387-0) contains supplementary material, which is available to authorized users.
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影响因子：
4.4
作者：
de Castro, JM
通讯作者：
de Castro, JM
影响因子：
2.9
作者：
DECASTRO, JM
通讯作者：
DECASTRO, JM
DOI：
10.1080/01639360802261920
发表时间：
2008-01-01
期刊：
Journal of Nutrition for the Elderly
影响因子：
--
作者：
Navarro-Allende, Alejandra;Khataan, Nora;El-Sohemy, Ahmed
通讯作者：
El-Sohemy, Ahmed
影响因子：
4.2
作者：
McCaffery, JM;Pogue-Geile, MF;Manuck, SB
通讯作者：
Manuck, SB
影响因子：
4
作者：
Henneman, P.;Aulchenko, Y. S.;van Duijn, C. M.
通讯作者：
van Duijn, C. M.