Peripheral mechanisms in appetite regulation.

Peripheral mechanisms in appetite regulation.
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DOI:
10.1053/j.gastro.2014.09.016
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发表时间:
2015-05
期刊:
影响因子:
29.4
通讯作者:
Camilleri M
Camilleri M
中科院分区:
医学1区
文献类型:
--
作者:
Camilleri M

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食欲调节的外周机制包括胃的运动功能,例如排空率和调节,其将饱食的症状传达给大脑。外周释放的肽和激素的丰富库提供了来自肠道不同区域中营养物到达的反馈,从这些区域释放营养物以对饱腹感产生影响,或通过其肠促胰岛素效应调节代谢。最终,这些外周因素提供输入到高度组织化的下丘脑回路和迷走神经核复合体,以确定进食期间能量摄入的停止,以及禁食后食欲和饥饿的恢复。了解这些机制是关键的生理控制喂养和紊乱发生在肥胖和恢复治疗(如减肥手术的效果所证明)。
Peripheral mechanisms in appetite regulation include the motor functions of the stomach, such as the rate of emptying and accommodation, which convey symptoms of satiation to the brain. The rich repertoire of peripherally released peptides and hormones provides feedback from the arrival of nutrients in different regions of the gut from where they are released to exert effects on satiation, or regulate metabolism through their incretin effects. Ultimately, these peripheral factors provide input to the highly organized hypothalamic circuitry and vagal complex of nuclei to determine cessation of energy intake during meal ingestion, and the return of appetite and hunger after fasting. Understanding these mechanisms is key to the physiological control of feeding and the derangements that occur in obesity and their restoration with treatment (as demonstrated by the effects of bariatric surgery).
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