Accelerated functional brain aging in pre-clinical familial Alzheimer's disease.
Accelerated functional brain aging in pre-clinical familial Alzheimer's disease.
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DOI：
10.1038/s41467-021-25492-9
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发表时间：
2021-09-09
影响因子：
16.6
通讯作者：
Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
中科院分区：
文献类型：
--
作者：
Gonneaud J;Baria AT;Pichet Binette A;Gordon BA;Chhatwal JP;Cruchaga C;Jucker M;Levin J;Salloway S;Farlow M;Gauthier S;Benzinger TLS;Morris JC;Bateman RJ;Breitner JCS;Poirier J;Vachon-Presseau E;Villeneuve S;Alzheimer’s Disease Neuroimaging Initiative (ADNI);Dominantly Inherited Alzheimer Network (DIAN) Study Group;Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
静息状态功能连接（rs-fMRI）受损的早期人谁随后发展阿尔茨海默氏病（AD）痴呆。这种损伤可用于辅助AD临床前阶段的研究。我们开发了一个模型，从静息状态（rs）-fMRI数据预测大脑年龄，并评估AD的遗传决定因素以及β淀粉样蛋白（Aβ）病理学是否可以加速大脑衰老。使用来自多个站点的1340名年龄在18-94岁之间的认知未受损参与者的数据，我们表明，从rs-fMRI构建的图形的拓扑特性可以预测整个生命周期的实际年龄。应用我们的预测模型的背景下，临床前AD显示，症状前阶段的常染色体显性AD包括加速功能性脑老化。这种关联在具有显著Aβ病理学的个体中更强。阿尔茨海默病与大脑结构老化有关。在这里，作者描述了一个模型，该模型从静息状态功能连接数据预测大脑衰老，并证明这在临床前家族性阿尔茨海默病患者中加速。
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer’s disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18–94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology. Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.
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影响因子：
11.2
作者：
FRATIGLIONI, L;AHLBOM, A;WINBLAD, B
通讯作者：
WINBLAD, B
影响因子：
5.7
作者：
Franke, Katja;Ziegler, Gabriel;Gaser, Christian
通讯作者：
Gaser, Christian
DOI：
10.1093/brain/awy008
发表时间：
2018-04-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Franzmeier N;Düzel E;Jessen F;Buerger K;Levin J;Duering M;Dichgans M;Haass C;Suárez-Calvet M;Fagan AM;Paumier K;Benzinger T;Masters CL;Morris JC;Perneczky R;Janowitz D;Catak C;Wolfsgruber S;Wagner M;Teipel S;Kilimann I;Ramirez A;Rossor M;Jucker M;Chhatwal J;Spottke A;Boecker H;Brosseron F;Falkai P;Fliessbach K;Heneka MT;Laske C;Nestor P;Peters O;Fuentes M;Menne F;Priller J;Spruth EJ;Franke C;Schneider A;Kofler B;Westerteicher C;Speck O;Wiltfang J;Bartels C;Araque Caballero MÁ;Metzger C;Bittner D;Weiner M;Lee JH;Salloway S;Danek A;Goate A;Schofield PR;Bateman RJ;Ewers M
通讯作者：
Ewers M
影响因子：
9.9
作者：
Chhatwal, Jasmeer P.;Schultz, Aaron P.;Sperling, Reisa A.
通讯作者：
Sperling, Reisa A.
DOI：
10.1024/1662-9647/a000074
发表时间：
2012-12-01
影响因子：
1
作者：
Franke, Katja;Gaser, Christian
通讯作者：
Gaser, Christian