Starvation, detoxification, and multidrug resistance in cancer therapy.
Starvation, detoxification, and multidrug resistance in cancer therapy.
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DOI：
10.1016/j.drup.2012.01.004
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发表时间：
2012-02
影响因子：
24.3
通讯作者：
Longo, Valter D.
中科院分区：
文献类型：
--
作者：
Lee, Changhan;Raffaghello, Lizzia;Longo, Valter D.
化疗药物的选择是基于对特定肿瘤细胞类型的细胞毒性和对正常细胞和组织相对较低的毒性。然而，对正常细胞的毒性是一个重大的临床挑战，特别是当恶性细胞对化疗产生耐药性时。癌细胞的耐药是由多种因素引起的，包括个体变异、肿瘤内的遗传异质性和细胞进化。在过去的35年里，由于诸如ABC转运蛋白的鉴定和表征等里程碑式的发现，对肿瘤细胞耐药性的理解取得了很大进展。尽管如此，癌细胞遗传和表观遗传重新布线的复杂性使得耐药性同样是一种难以克服的复杂现象。在这篇综述中，我们讨论了空腹引起的葡萄糖、IGF-I、IGFBP-1和其他蛋白水平的显著变化如何通过保护正常细胞和组织以及可能通过减少恶性细胞的多药耐药来提高化疗对肿瘤的疗效。
The selection of chemotherapy drugs is based on the cytotoxicity to specific tumor cell types and the relatively low toxicity to normal cells and tissues. However, the toxicity to normal cells poses a major clinical challenge, particularly when malignant cells have acquired resistance to chemotherapy. This drug resistance of cancer cells results from multiple factors including individual variation, genetic heterogeneity within a tumor, and cellular evolution. Much progress in the understanding of tumor cell resistance has been made in the past 35 years, owing to milestone discoveries such as the identification and characterization of ABC transporters. Nonetheless, the complexity of the genetic and epigenetic rewiring of cancer cells makes drug resistance an equally complex phenomenon that is difficult to overcome. In this review, we discuss how the remarkable changes in the levels of glucose, IGF-I, IGFBP-1 and in other proteins caused by fasting have the potential to improve the efficacy of chemotherapy against tumors by protecting normal cells and tissues and possibly by diminishing multidrug resistance in malignant cells.
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影响因子：
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作者：
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