Relationship of liver fat content with systemic metabolism and chronic complications in patients with type 2 diabetes mellitus.
Relationship of liver fat content with systemic metabolism and chronic complications in patients with type 2 diabetes mellitus.
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DOI：
10.1186/s12944-023-01775-6
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发表时间：
2023-01-24
影响因子：
4.5
通讯作者：
Ran, Jianmin
中科院分区：
文献类型：
--
作者：
Ren, Weiwei;Feng, Yunlu;Feng, Youzhen;Li, Jiaying;Zhang, Chuangbiao;Feng, Lie;Cui, Lijuan;Ran, Jianmin
This study investigated the correlation of liver fat content (LFC) with metabolic characteristics and its association with chronic complications in type 2 diabetes mellitus (T2DM) patients. Eighty-one prospectively enrolled T2DM patients were divided into non-alcoholic fatty liver disease (NAFLD) group and the non-NAFLD group according to the presence of NAFL complications. LFC was determined by MRI IDEAL-IQ Sequence, and patients were divided into 4 groups according to LFC by quartile method. Basic information, metabolic indexes, and occurrence of chronic complications in different groups were analyzed and compared. BMI, SBP, DBP, TG, ALT, AST, GGT, UA, HbA1c, FCP, 2 h CP, HOMA-IR, and HOMA-IS in the NAFLD group were significantly higher than the non-NAFLD group (P < 0.05). The incidences of chronic complications in the NAFLD group were higher than in the non-NAFLD group but not statistically significant (P > 0.05). BMI, SBP, DBP, TC, TG, ALT, AST, FCP, 2 h CP, HOMA-IR, and HOMA-IS showed significant differences between the patients with different LFC, and these indexes were significantly higher in patients with higher LFC than those with lower LFC (P < 0.05). Moreover, diabetes duration, TC, HOMA-IR, and LFC were the risk factors for ASCVD complications, while diabetes duration, TG, and LDL-C were risk factors for DN complications. Also, diabetes duration and SBP were risk factors for both DR and DPN complications in T2DM patients (P < 0.05). LFC is positively correlated with the severity of the systemic metabolic disorder and chronic complications in T2DM patients.
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影响因子：
8.3
作者：
McGlinchey, Aidan J.;Govaere, Olivier;Geng, Dawei;Ratziu, Vlad;Allison, Michael;Bousier, Jerome;Petta, Salvatore;de Oliviera, Claudia;Bugianesi, Elisabetta;Schattenberg, Jorn M.;Daly, Ann K.;Hyotylainen, Tuulia;Anstee, Quentin M.;Oresic, Matej
通讯作者：
Oresic, Matej
影响因子：
3.1
作者：
Nobarani, Sohrab;Alaei-Shahmiri, Fariba;Khamseh, Mohammad E.
通讯作者：
Khamseh, Mohammad E.
影响因子：
5.9
作者：
Chen YY;Chen YJ
通讯作者：
Chen YJ
影响因子：
9.8
作者：
Fain, John N.;Buehrer, Ben;Madan, Atul K.
通讯作者：
Madan, Atul K.
影响因子：
3.7
作者：
Gonzalez-Cantero J;Martin-Rodriguez JL;Gonzalez-Cantero A;Arrebola JP;Gonzalez-Calvin JL
通讯作者：
Gonzalez-Calvin JL