Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans.
Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans.
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DOI：
10.1002/oby.22128
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Xiang AH
中科院分区：
文献类型：
--
作者：
Black MH;Shu YH;Wu J;Koebnick C;MacKay A;Watanabe RM;Buchanan TA;Xiang AH
有限的研究已经评估了肥胖的纵向变化与多种脂肪因子随时间变化之间的关系。我们研究了具有2型糖尿病风险的墨西哥裔美国人的BMI、全身和躯干脂肪的变化与16种循环脂肪因子变化的相关性。参与者包括1，213名具有横断面数据的个体和368名具有随访措施的个体的子集（从基线开始平均4.6±1.5年）。通过典型相关分析评估了3种肥胖指标和16种脂肪因子之间的联合多变量关联。随着时间的推移，肥胖的纵向增加与瘦素、CRP和IL-1 Ra的增加以及脂联素和SFRP 5的减少密切相关。基线时BMI ≥ 30 kg/m2的参与者与BMI <30 kg/m2的参与者相比，瘦素、CRP、IL-1 Ra和IL-6的增加更大，脂联素和SFRP 5的降低更大，与随访期间肥胖增加相关。肥胖和脂肪因子之间的关联主要由瘦素解释;瘦素的调整大大降低了肥胖和剩余脂肪因子之间所有关联的程度。随着时间的推移，肥胖的增加会导致促炎和抗炎脂肪因子的不平衡加剧，其中瘦素可能作为墨西哥裔美国人代谢疾病风险的关键介导因子发挥重要作用。
Limited studies have assessed the relationship between longitudinal changes in adiposity and changes in multiple adipokines over time. We examined changes in BMI, total body and trunk fat associated with changes in 16 circulating adipokines in Mexican Americans at risk for type 2 diabetes. Participants included 1,213 individuals with cross-sectional data and a subset of 368 individuals with follow-up measures (mean 4.6±1.5 years from baseline). Joint multivariate associations between 3 adiposity measures and 16 adipokines were assessed by canonical correlation analysis. Longitudinal increases in adiposity were most strongly associated with increasing leptin, CRP and IL-1Ra, and decreasing adiponectin and SFRP5 over time. Participants with BMI ≥ 30 kg/m2 at baseline had greater increases in leptin, CRP, IL-1Ra, and IL-6, and greater decreases in adiponectin and SFRP5, associated with increasing adiposity over follow-up than those with BMI <30 kg/m2. Associations between adiposity and adipokines were most accounted for by leptin; adjustment for leptin greatly reduced the magnitude of all associations between adiposity and remaining adipokines. Increasing adiposity contributes to a worsening imbalance of pro- and anti-inflammatory adipokines over time, in which leptin may have an important role as a key mediator of metabolic disease risk in Mexican Americans.
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影响因子：
8.2
作者：
Lee, C. C.;Lorenzo, C.;Haffner, S. M.;Wagenknecht, L. E.;Festa, A.;Goodarzi, M. O.;Stefanovski, D.;Olson, N. C.;Norris, J. M.;Rewers, M. J.;Hanley, A. J.
通讯作者：
Hanley, A. J.
影响因子：
22.4
作者：
KNAPP, TR
通讯作者：
KNAPP, TR
DOI：
10.1152/ajpendo.00110.2003
发表时间：
2003-09-01
影响因子：
5.1
作者：
Bruun, JM;Lihn, AS;Richelsen, B
通讯作者：
Richelsen, B
影响因子：
3.7
作者：
Schulte DM;Müller N;Neumann K;Oberhäuser F;Faust M;Güdelhöfer H;Brandt B;Krone W;Laudes M
通讯作者：
Laudes M
影响因子：
9.8
作者：
Ruth, Megan R.;Port, Ava M.;Shah, Mitali;Bourland, Ashley C.;Istfan, Nawfal W.;Nelson, Kerrie P.;Gokce, Noyan;Apovian, Caroline M.
通讯作者：
Apovian, Caroline M.