Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects.
Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects.
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DOI：
10.1016/j.metabol.2013.07.006
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发表时间：
2013-12
影响因子：
9.8
通讯作者：
Apovian, Caroline M.
中科院分区：
文献类型：
--
作者：
Ruth, Megan R.;Port, Ava M.;Shah, Mitali;Bourland, Ashley C.;Istfan, Nawfal W.;Nelson, Kerrie P.;Gokce, Noyan;Apovian, Caroline M.
高脂肪，低碳水化合物（HFLC）饮食已成为流行的体重管理工具。我们试图确定HFLC饮食与低脂高碳水化合物（LFHC）饮食相比对肥胖受试者体重减轻，心血管危险因素和炎症变化的影响。从波士顿医学中心招募的肥胖受试者（29.0-44.6 kg/m2）随机接受低热量LFHC（n=26）或HFLC（n=29）饮食12周。受试者的年龄范围为21-62岁。HFLC组消耗33.5%蛋白质、56.0%脂肪和9.6%碳水化合物，LFHC组消耗22.0%蛋白质、25.0%脂肪和55.7%碳水化合物。12周后，两种饮食之间的体重百分比、瘦体重和脂肪质量、血压、血流介导的扩张、臀腰比、血红蛋白A1 C、空腹胰岛素和葡萄糖以及对2小时口服葡萄糖耐量试验的葡萄糖和胰岛素反应的变化没有差异（P>0.05）。与LFHC组相比，HFLC组血清甘油三酯（P=0.07）和hs-CRP（P=0.03）的平均下降幅度更大，HDL胆固醇（P=0.004）和总脂联素（P=0.045）的平均增加幅度更大。在体重减轻后，两种饮食的脂肪组织脂联素或TNF-α分泌量没有差异。相对于LFHC组，HFLC组在血脂和全身炎症方面有更大的改善，体重和成分的变化相似。这项小规模的研究表明，与LFHC饮食相比，HFLC饮食可能对自由生活的肥胖成年人的心血管健康和炎症更有益。
High fat, low carbohydrate (HFLC) diets have become popular tools for weight management. We sought to determine the effects of a HFLC diet compared to a low fat high carbohydrate (LFHC) diet on the change in weight loss, cardiovascular risk factors and inflammation in subjects with obesity. Obese subjects (29.0–44.6 kg/m2) recruited from Boston Medical Center were randomized to a hypocaloric LFHC (n=26) or HFLC (n=29) diet for 12 weeks. The age range of subjects was 21–62 years. As a percentage of daily calories, the HFLC group consumed 33.5% protein, 56.0% fat and 9.6% carbohydrate and the LFHC group consumed 22.0% protein, 25.0% fat and 55.7% carbohydrate. The change in percent body weight, lean and fat mass, blood pressure, flow mediated dilation, hip:waist ratio, hemoglobin A1C, fasting insulin and glucose, and glucose and insulin response to a 2 h oral glucose tolerance test did not differ (P>0.05) between diets after 12 weeks. The HFLC group had greater mean decreases in serum triglyceride (P=0.07), and hs-CRP (P=0.03), and greater mean increases in HDL cholesterol (P=0.004), and total adiponectin (P=0.045) relative to the LFHC. Secreted adipose tissue adiponectin or TNF-α did not differ after weight loss for either diet. Relative to the LFHC group, the HFLC group had greater improvements in blood lipids and systemic inflammation with similar changes in body weight and composition. This small-scale study suggests that HFLC diets may be more beneficial to cardiovascular health and inflammation in free-living obese adults compared to LFHC diets.
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影响因子：
9.8
作者：
Behre, Carl Johan;Gummesson, Anders;Carlsson, Lena M. S.
通讯作者：
Carlsson, Lena M. S.
影响因子：
7.7
作者：
Bradley, Una;Spence, Michelle;Hunter, Steven J.
通讯作者：
Hunter, Steven J.
影响因子：
4.8
作者：
Clément, K;Viguerie, N;Langin, D
通讯作者：
Langin, D
影响因子：
7.1
作者：
Keogh, Jennifer B.;Brinkworth, Grant D.;Clifton, Peter M.
通讯作者：
Clifton, Peter M.
影响因子：
8.3
作者：
Phillips, Shane A.;Jurva, Jason W.;Gutterman, David D.
通讯作者：
Gutterman, David D.