Alcohol-induced depressive-like behavior is associated with cortical norepinephrine reduction.
Alcohol-induced depressive-like behavior is associated with cortical norepinephrine reduction.
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DOI：
10.1016/j.pbb.2010.06.011
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发表时间：
2010-10
影响因子：
3.6
通讯作者：
Tizabi, Yousef
中科院分区：
文献类型：
--
作者：
Getachew, Bruk;Hauser, Sheketha R.;Taylor, Robert E.;Tizabi, Yousef
关键词：
虽然酒精中毒和抑郁症之间的强正相关是一个常见的流行病学观察，因果关系和神经生物学基板等意见还远不清楚。我们已经报道了大鼠长期每日暴露于相对高剂量的酒精可以诱导或加剧已经存在的抑郁样行为（Pharm Biochem Behav 91：97-103，2008）。此外，这些影响的酒精被阻断预处理与地昔帕明，三环类抗抑郁药，暗示作用的生物胺在这种类型的抑郁症状。为了进一步阐明特定的神经递质参与酒精诱导的抑郁症状，我们检查了去甲肾上腺素（NE），多巴胺（DA）和5-羟色胺（5-HT）的浓度在额叶皮层和海马酒精管理以及预处理与两种抗抑郁药，诺米芬新和丙咪嗪选择性NE/DA和NE/5-HT摄取抑制剂，分别。成年雌性Wistar和Wistar-Kyoto（WKY）大鼠通过吸入室暴露于酒精（3小时/天，持续10天），以达到每日血液酒精浓度约为150 mg%。在第11天，评价动物的一般运动活动（LCA）和强迫游泳试验（FST）中的表现，然后进行神经化学分析。与Wistar大鼠相比，WKY具有较低的LCA和较高的不动FST。WKY大鼠也有较低水平的所有三个生物胺相比，Wistar大鼠在这两个领域。然而，只有皮质NE减少酒精管理后，在两个菌株。诺米芬辛和丙咪嗪治疗可以阻止这两种菌株中酒精引起的行为和大部分神经化学缺陷。这些结果暗示皮质NE作为酒精诱导的抑郁症的主要参与者。此外，它表明，选择性NE摄取抑制剂可能是特别的治疗潜力，在共病条件下的酒精中毒和抑郁症。
Although strong positive association between alcoholism and depression is a common epidemiological observance, the causal relationship and the neurobiological substrates of such observations are far from clear. We have reported that chronic daily exposure to a relatively high dose of alcohol in rats can induce or exacerbate an already existing depressive-like behavior (Pharm Biochem Behav 91:97-103, 2008). Moreover, these effects of alcohol were blocked by pretreatment with desipramine, a tricyclic antidepressant, implicating a role for the biogenic amines in this type of depressive symptoms. In order to further delineate the involvement of specific neurotransmitters in alcohol-induced depressive symptoms, we examined the concentrations of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) in the frontal cortex and hippocampus following alcohol administration as well as pretreatment with two antidepressants, nomifensine and imipramine selective NE/DA and NE/5-HT uptake inhibitors, respectively. Adult female Wistar and Wistar-Kyoto (WKY) rats were exposed to alcohol via inhalation chambers (3 hr/day for 10 days) to achieve daily blood alcohol concentration of approximately 150 mg%. On day 11, the animals were evaluated for general locomotor activity (LCA) and performance in the forced swim test (FST), followed by neurochemical analyses. As expected WKY had lower LCA and higher immobile FST compared to Wistar rats. WKY rats also had lower levels of all three biogenic amines compared to Wistar rats in both areas. However, only cortical NE was reduced in both strains following alcohol administration. Treatments with nomifensine and imipramine blocked the behavioral and most of the neurochemical deficits caused by alcohol in both strains. These results implicate cortical NE as a major player in alcohol-induced depression. Moreover, it is suggested that selective NE uptake inhibitors may be of particular therapeutic potential in co-morbid condition of alcoholism and depression.
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影响因子：
3.6
作者：
Getachew, Bruk;Hauser, Sheketha R.;Tizabi, Yousef
通讯作者：
Tizabi, Yousef
影响因子：
11
作者：
Laine, TPJ;Ahonen, A;Hillbom, M
通讯作者：
Hillbom, M
影响因子：
7.6
作者：
López-Rubalcava, C;Lucki, I
通讯作者：
Lucki, I
影响因子：
6.9
作者：
Kessler, RC;Davis, CG;Kendler, KS
通讯作者：
Kendler, KS
DOI：
10.1097/00000374-200001000-00016
发表时间：
2000-01-01
影响因子：
3.2
作者：
Lee, S;Schmidt, D;Rivier, C
通讯作者：
Rivier, C