MicroRNAs as Mediators of the Ageing Process.
MicroRNAs as Mediators of the Ageing Process.
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DOI：
10.3390/genes5030656
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发表时间：
2014-08-20
期刊：
影响因子：
3.5
通讯作者：
Harries LW
中科院分区：
文献类型：
--
作者：
Harries LW
人的衰老是一个复杂而综合的细胞逐渐退化的过程。衰老有九个主要标志，包括DNA修复和DNA损伤反应的变化、端粒缩短、表观遗传和mRNA加工变化引起的基因表达和调控控制的变化、蛋白质稳态的丧失、营养信号的改变、线粒体功能障碍、干细胞衰竭、细胞过早衰老和细胞内通讯的改变。与几乎所有其他细胞过程一样，与衰老特征相关的基因受到miRNA的调控。在这篇综述中，我将概述衰老的每一个特征，以及已被证明参与每一个特征的特定miRNA的例子。这将证明参与人类衰老的转录调控的相互关联性，以及miRNAs在这一过程中的作用。生物体、组织和细胞内稳态退化所涉及的因素的定义可能为健康老龄化提供生物标志物，并增加对支撑老龄化过程本身的过程的理解。
Human ageing is a complex and integrated gradual deterioration of cellular processes. There are nine major hallmarks of ageing, that include changes in DNA repair and DNA damage response, telomere shortening, changes in control over the expression and regulation of genes brought about by epigenetic and mRNA processing changes, loss of protein homeostasis, altered nutrient signaling, mitochondrial dysfunction, stem cell exhaustion, premature cellular senescence and altered intracellular communication. Like practically all other cellular processes, genes associated in features of ageing are regulated by miRNAs. In this review, I will outline each of the features of ageing, together with examples of specific miRNAs that have been demonstrated to be involved in each one. This will demonstrate the interconnected nature of the regulation of transcripts involved in human ageing, and the role of miRNAs in this process. Definition of the factors involved in degeneration of organismal, tissue and cellular homeostasis may provide biomarkers for healthy ageing and increase understanding of the processes that underpin the ageing process itself.
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