Plant sphingolipids: decoding the enigma of the Sphinx.
Plant sphingolipids: decoding the enigma of the Sphinx.
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DOI：
10.1111/j.1469-8137.2009.03123.x
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
Ng CK
中科院分区：
文献类型：
--
作者：
Pata MO;Hannun YA;Ng CK
鞘脂是一种普遍存在于包括真核生物和细菌在内的多种生物中的脂类。在过去的二十年里，研究的重点是表征这种复杂脂质家族的单个物种，从而产生了一个新的研究领域，称为鞘脂组学。细胞中至少有500种（也许是数千种）不同的鞘脂分子种类，仅在拟南芥中，就有报道称至少有168种不同的鞘脂。植物鞘脂可分为四类：糖基肌醇磷酸神经酰胺（GIPCs）、糖基神经酰胺、神经酰胺和游离长链碱（LCBs）。许多参与植物鞘脂代谢的酶现已被克隆和鉴定，总的来说，鞘脂在动物、酵母和植物中的代谢方式具有广泛的保守性。本文综述了鞘脂的多样性、植物鞘脂代谢的最新进展，以及鞘脂和鞘脂代谢物在植物生理中的作用。
Sphingolipids are a ubiquitous class of lipids present in a variety of organisms including eukaryotes and bacteria. In the last two decades, research has focused on characterizing the individual species of this complex family of lipids, leading to a new field of research called sphingolipidomics. There are at least 500 (and perhaps thousands) different molecular species of sphingolipids in cells, and in Arabidopsis alone, it has been reported that there are at least 168 different sphingolipids. Plant sphingolipids can be divided into four classes: glycosyl inositol phosphoceramides (GIPCs), glycosylceramides, ceramides, and free long chain bases (LCBs). Numerous enzymes involved in plant sphingolipid metabolism have now been cloned and characterized, and, in general, there is broad conservation in the way sphingolipids are metabolized in animals, yeast and plants. Here, we review the diversity of sphingolipids reported in the literature, some of the recent advances in our understanding of sphingolipid metabolism in plants, and the physiological roles that sphingolipids and sphingolipid metabolites play in plant physiology.
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