Antidepressants increase neural progenitor cells in the human hippocampus.
Antidepressants increase neural progenitor cells in the human hippocampus.
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抗抑郁药会增加人海马中的神经祖细胞。
DOI：
10.1038/npp.2009.75
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发表时间：
2009-10
影响因子：
7.6
通讯作者：
Arango, Victoria
中科院分区：
文献类型：
--
作者：
Boldrini, Maura;Underwood, Mark D.;Hen, Rene;Rosoklija, Gorazd B.;Dwork, Andrew J.;Mann, J. John;Arango, Victoria
选择性5 -羟色胺再摄取抑制剂（SSRIs）和三环抗抑郁药（TCAs）增加啮齿动物和非人灵长类动物齿状回（DG）的神经发生。我们确定了SSRIs或TCAs是否会增加重度抑郁症（MDD）患者DG中的神经祖细胞（npc）和分裂细胞。对未经治疗的MDD （N = 5）、经抗抑郁药物治疗的MDD （MDDT, N = 7）和对照组（C, N = 7）的整个冷冻海马进行固定、切片和免疫染色，检测npc和分裂细胞标志物（分别为nestin和Ki-67）、NeuN和GFAP，分别采用单标记和双标记。用体视学方法估计鼻咽癌和DG中的分裂细胞数。所有受试者均通过心理解剖、毒理学和神经病理学检查获得临床资料。npc随着年龄的增长而减少（p = 0.034）。女性拥有比男性更多的npc （p = 0.023）。校正年龄和性别，接受SSRIs治疗的MDDT比未治疗的MDD有更多的npc （p≤0.001）和对照组（p≤0.001），非npc在SSRIs和tcas治疗的MDDT中没有差异（p = 0.169）。接受TCAs治疗的MDDT患者的分裂细胞数量不受年龄或性别影响，高于未治疗的MDD患者（p≤0.001）、ssri治疗的MDD患者（p = 0.001）和对照组（p≤0.001）。MDDT的NPCs和分裂细胞的增加局限于吻侧DG。与未治疗的MDD或对照组相比，MDDT的DG体积更大（p = 0.009）。抗抑郁药增加人类前齿状回的神经祖细胞数量。这一发现对于抗抑郁药的作用是否至关重要或必要还有待确定。
Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) increase neurogenesis in the dentate gyrus (DG) of rodents and nonhuman primates. We determined whether SSRIs or TCAs increase neural progenitor (NPCs) and dividing cells in the human DG in major depressive disorder (MDD). Whole frozen hippocampi from untreated subjects with MDD (N = 5), antidepressant-treated MDD (MDDT, N = 7), and controls (C, N = 7) were fixed, sectioned and immunostained for NPCs and dividing cell markers (nestin and Ki-67 respectively), NeuN and GFAP, in single and double labeling. NPC and dividing cell numbers in the DG were estimated by stereology. Clinical data were obtained by psychological autopsy and toxicological and neuropathological examination performed in all subjects. NPCs decreased with age (p = 0.034). Females had more NPCs than males (p = 0.023). Correcting for age and sex, MDDT receiving SSRIs had more NPCs than untreated MDD (p ≤ 0.001) and controls (p ≤ 0.001), NPCs were not different in SSRIs- and TCAs-treated MDDT (p = 0.169). Dividing cell number, unaffected by age or sex, was greater in MDDT receiving TCAs than in untreated MDD (p ≤ 0.001), SSRI-treated MDD (p = 0.001) and controls (p ≤ 0.001). The NPCs and dividing cells increase in MDDT was localized to the rostral DG. MDDT had a larger DG volume compared with untreated MDD or controls (p = 0.009). Antidepressants increase neural progenitor cell number in the anterior human dentate gyrus. Whether this finding is critical or necessary for the antidepressants effect remains to be determined.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
2.5
作者：
Dayer, AG;Ford, AA;Cameron, HA
通讯作者：
Cameron, HA
影响因子：
2.5
作者：
Colombo, M;Fernandez, T;Gross, CG
通讯作者：
Gross, CG
影响因子：
10.6
作者：
Duman, RS;Malberg, J;D'Sa, C
通讯作者：
D'Sa, C
DOI：
10.1073/pnas.0601992103
发表时间：
2006-05-23
影响因子：
11.1
作者：
Encinas, Juan M.;Vaahtokari, Anne;Enikolopov, Grigori
通讯作者：
Enikolopov, Grigori