Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice.
Exposure to permethrin promotes high fat diet-induced weight gain and insulin resistance in male C57BL/6J mice.
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DOI：
10.1016/j.fct.2017.11.047
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Park Y
中科院分区：
文献类型：
--
作者：
Xiao X;Sun Q;Kim Y;Yang SH;Qi W;Kim D;Yoon KS;Clark JM;Park Y
氯菊酯是一种拟除虫菊酯类杀虫剂，以前曾报道在体外可促进脂肪积累和胰岛素抵抗。最近对雌性小鼠的一项研究也发现，氯菊酯可以促进高脂肪诱导的胰岛素抵抗。然而，氯菊酯对雄性小鼠葡萄糖和脂质代谢的影响仍不清楚。本研究的目的是研究氯菊酯暴露（50、500和5000 μg/kg体重/天）和膳食脂肪（低脂，4% w/w;高脂，20% w/w）对雄性C57 BL/6 J小鼠肥胖和胰岛素抵抗发展的影响和相互作用。我们的研究结果表明，氯菊酯治疗显着增加体重，脂肪量，胰岛素抵抗与高脂肪饮食，但不与低脂饮食，不影响能量摄入。氯菊酯治疗也显着增加血清胰岛素，葡萄糖，瘦素，甘油三酯和胆固醇水平。进一步的结果表明，氯菊酯抑制白色脂肪组织中AMP活化的蛋白激酶。这些结果表明，氯菊酯与膳食脂肪相互作用，改变脂质和葡萄糖代谢在雄性C57 BL/6 J小鼠。
Permethrin is a pyrethroid pesticide that was previously reported to promote fat accumulation and insulin resistance in vitro. A recent study in female mice also found that permethrin could promote high fat-induced insulin resistance. The effects of permethrin on glucose and lipid metabolisms in male mice, however, remain unknown. The purpose of this study was to investigate the effects and interactions of permethrin exposure (50, 500, and 5000 μg/kg body weight/day) and dietary fat (low fat, 4% w/w; high fat, 20% w/w) on development of obesity and insulin resistance in male C57BL/6J mice. Our results showed that permethrin treatment significantly increased body weight, fat mass, and insulin resistance with high fat diet, but not with low fat diet, without influencing energy intake. Permethrin treatment also significantly increased serum levels of insulin, glucose, leptin, triglycerides and cholesterol. Further results showed that permethrin inhibited AMP-activated protein kinase in white adipose tissue. These results suggest that permethrin interacts with dietary fat to alter lipid and glucose metabolisms in male C57BL/6J mice.
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