Changes in topological organization of functional PET brain network with normal aging.
Changes in topological organization of functional PET brain network with normal aging.
复制标题
正常衰老过程中功能性 PET 脑网络拓扑结构的变化
DOI：
10.1371/journal.pone.0088690
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Hu Z
中科院分区：
文献类型：
--
作者：
Liu Z;Ke L;Liu H;Huang W;Hu Z
近年来有关脑网络的研究表明，正常衰老与脑大尺度功能和结构系统协调模式的改变有关。然而，通过正电子发射断层扫描（PET）数据构建的功能网络中与年龄相关的变化仍然很少被理解。在这里，我们用PET数据构建了由年轻（平均年龄）和老年（平均年龄）年龄组的区域组成的功能性大脑网络。从体格检查数据库中分别选择年轻和年长的健康个体作为两个年龄组。通过阈值化脑葡萄糖代谢相关矩阵构建两组脑功能网络，并利用图论方法进行分析。尽管两组受试者的PET网络都显示出正常的小世界结构，但在老年受试者中发现了聚类增加和效率降低，这意味着随着正常衰老，大脑系统从小世界网络向规则网络转变的退化过程。此外，正常衰老与主要在联合和边缘皮质区域的节点中心性变化有关，例如，眶额皮质（中间）增加，左侧海马减少。此外，较老的网络对随机故障的鲁棒性与较年轻的网络一样，但更容易受到有针对性的攻击。最后，PET网络的构建方法显示出合理的鲁棒性。我们的研究结果加深了对PET网络的拓扑原理以及与正常衰老相关的变化的理解。
Recent studies about brain network have suggested that normal aging is associated with alterations in coordinated patterns of the large-scale brain functional and structural systems. However, age-related changes in functional networks constructed via positron emission tomography (PET) data are still barely understood. Here, we constructed functional brain networks composed of regions in younger (mean age years) and older (mean age years) age groups with PET data. younger and older healthy individuals were separately selected for two age groups, from a physical examination database. Corresponding brain functional networks of the two groups were constructed by thresholding average cerebral glucose metabolism correlation matrices of regions and analysed using graph theoretical approaches. Although both groups showed normal small-world architecture in the PET networks, increased clustering and decreased efficiency were found in older subjects, implying a degeneration process that brain system shifts from a small-world network to regular one along with normal aging. Moreover, normal senescence was related to changed nodal centralities predominantly in association and paralimbic cortex regions, e.g. increasing in orbitofrontal cortex (middle) and decreasing in left hippocampus. Additionally, the older networks were about equally as robust to random failures as younger counterpart, but more vulnerable against targeted attacks. Finally, methods in the construction of the PET networks revealed reasonable robustness. Our findings enhanced the understanding about the topological principles of PET networks and changes related to normal aging.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
5.7
作者：
Dukart, Juergen;Mueller, Karsten;Schroeter, Matthias L.
通讯作者：
Schroeter, Matthias L.
影响因子：
1.7
作者：
Bluhm, Robyn L.;Osuch, Elizabeth A.;Williamson, Peter
通讯作者：
Williamson, Peter