Hypertension and urologic chronic pelvic pain syndrome: An analysis of MAPP-I data.
Hypertension and urologic chronic pelvic pain syndrome: An analysis of MAPP-I data.
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DOI：
10.1186/s12894-024-01407-w
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发表时间：
2024-01-28
期刊：
影响因子：
2
通讯作者：
Mickle, Aaron D.
中科院分区：
文献类型：
--
作者：
Conic, Rosalynn R. Z.;Vasilopoulos, Terrie;Devulapally, Karthik;Przkora, Rene;Dubin, Andrew;Sibille, Kimberly T.;Mickle, Aaron D.
关键词：
尿路慢性盆腔疼痛综合征(UCPPS)包括间质性膀胱炎/膀胱疼痛综合征(IC/BPS)和慢性前列腺炎(CP/CPPS)，与排尿频率增加、夜尿和慢性盆腔疼痛有关。这些疾病的原因尚不清楚，可能涉及许多不同的机制。肾素-血管紧张素-醛固酮系统(RAAS)信号转导异常是IC/BPS和CP/CPPS的潜在病理机制。许多血管紧张素受体下游信号因子，包括氧化应激、纤维化、肥大细胞募集和炎性介质增加，存在于IC/BPS患者的膀胱和CP/CPPS患者的前列腺中。因此，我们的目的是验证UCPPS患者血管紧张素信号异常，导致与对照组相比高血压增加的假设。其次，我们评估了高血压患者和非高血压患者的症状严重程度以及降压药的使用情况。UCPPS患者(n = 424例)、纤维肌痛或肠易激综合征患者(n = 200例)和健康对照组(n = 415例)的数据来自NIDDKI慢性盆腔疼痛多学科研究方法(MAPP-I)。用卡方检验和t检验分析高血压的诊断、目前的降压药物、疼痛严重程度和泌尿症状严重程度。UCPPS组的诊断和降压药物联合用药比例最高(n = 74，18%)，其次是阳性(n = 34，17%)和健康对照组(n = 48，12%，p = 0.0 4)。两组患者基于高血压的症状严重程度无差异，但IC/BPS组的ICSI(p = 0.031.0 5)、AUA-SI(p = 0.0 4)和BPI0.02疼痛程度较差。未服用降压药的高血压患者(n = 7)报告的疼痛和尿路症状最严重。这一模式的发现表明，高血压和UCPPS之间可能存在关系。在这些患者中治疗高血压可能会减轻疼痛和症状严重程度。需要进一步研究高血压、抗高血压药物的使用和UCPPS之间的关系，以及血管紧张素信号在UCPPS中的作用。网上版载有补充材料，可在10.1186/s12894-024-01407-w查阅。
Urologic chronic pelvic pain syndrome (UCPPS), which includes interstitial cystitis/bladder pain syndrome (IC/BPS) and chronic prostatitis (CP/CPPS), is associated with increased voiding frequency, nocturia, and chronic pelvic pain. The cause of these diseases is unknown and likely involves many different mechanisms. Dysregulated renin-angiotensin-aldosterone-system (RAAS) signaling is a potential pathologic mechanism for IC/BPS and CP/CPPS. Many angiotensin receptor downstream signaling factors, including oxidative stress, fibrosis, mast cell recruitment, and increased inflammatory mediators, are present in the bladders of IC/BPS patients and prostates of CP/CPPS patients. Therefore, we aimed to test the hypothesis that UCPPS patients have dysregulated angiotensin signaling, resulting in increased hypertension compared to controls. Secondly, we evaluated symptom severity in patients with and without hypertension and antihypertensive medication use. Data from UCPPS patients (n = 424), fibromyalgia or irritable bowel syndrome (positive controls, n = 200), and healthy controls (n = 415) were obtained from the NIDDK Multidisciplinary Approach to the Study of Chronic Pelvic Pain I (MAPP-I). Diagnosis of hypertension, current antihypertensive medications, pain severity, and urinary symptom severity were analyzed using chi-square test and t-test. The combination of diagnosis and antihypertensive medications use was highest in the UCPPS group (n = 74, 18%), followed by positive (n = 34, 17%) and healthy controls (n = 48, 12%, p = 0.04). There were no differences in symptom severity based on hypertension in UCPPS and CP/CPPS; however, IC/BPS had worse ICSI (p = 0.031), AUA-SI (p = 0.04), and BPI pain severity (0.02). Patients (n = 7) with a hypertension diagnosis not on antihypertensive medications reported the greatest severity of pain and urinary symptoms. This pattern of findings suggests that there may be a relationship between hypertension and UCPPS. Treating hypertension among these patients may result in reduced pain and symptom severity. Further investigation on the relationship between hypertension, antihypertensive medication use, and UCPPS and the role of angiotensin signaling in UCPPS conditions is needed. The online version contains supplementary material available at 10.1186/s12894-024-01407-w.
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影响因子：
4.5
作者：
Dagher A;Curatolo A;Sachdev M;Stephens AJ;Mullins C;Landis JR;van Bokhoven A;El-Hayek A;Froehlich JW;Briscoe AC;Roy R;Yang J;Pontari MA;Zurakowski D;Lee RS;Moses MA;MAPP Research Network
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DOI：
10.1016/j.ijchy.2020.100044
发表时间：
2020-09
期刊：
International Journal of Cardiology. Hypertension
影响因子：
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作者：
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Nfor T
DOI：
10.1016/j.juro.2011.03.132
发表时间：
2011-08
期刊：
The Journal of urology
影响因子：
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通讯作者：
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