Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States.
Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States.
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DOI：
10.1016/j.juro.2011.03.132
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发表时间：
2011-08
期刊：
影响因子：
--
通讯作者：
Clemens JQ
中科院分区：
文献类型：
--
作者：
Berry SH;Elliott MN;Suttorp M;Bogart LM;Stoto MA;Eggers P;Nyberg L;Clemens JQ
膀胱疼痛综合征/间质性膀胱炎是一种可能导致严重残疾的疾病。我们为美国成年女性的知识提供了第一个基于人群的症状患病率估计。
我们开发了2个病例定义，以鉴定膀胱疼痛综合征/间质性膀胱炎症状。从2007年8月开始，我们打电话给美国家庭，寻找患有膀胱症状的成年妇女或膀胱疼痛综合征/间质性膀胱炎的诊断。第二阶段筛查确定了符合案例定义标准的受试者。每个人都完成了60分钟的访谈，以了解膀胱症状，寻求医疗保健和人口统计的严重性和影响。数据收集于2009年4月结束。使用种群和无响应权重，我们根据跨越一系列敏感性和特异性的定义计算出患病率估计值。我们使用美国的人口普查计数来估计2006年受影响妇女的数量。随机样本包括146,231户家庭，其中131,691个包括成年女性。在这些家庭中，有32,474个报告了一名具有膀胱症状或诊断的成年女性，其中12,752名完成了问卷。
根据高灵敏度定义，女性的妇女为6.53％（95％CI 6.28，6.79）符合症状标准。根据高特异性定义，妇女的2.70％（95％CI 2.53，2.86）符合标准。这些百分比转化为3.3至790万美国妇女18岁或以上的膀胱疼痛综合征/间质性膀胱炎症状。症状严重程度和影响与有诊断的成年妇女的症状相当。但是，只有9.7％的妇女报告被指定为膀胱疼痛综合征/间质性膀胱炎的诊断。
膀胱疼痛综合征/间质性膀胱炎的症状在美国妇女中普遍存在，并且与大量残疾有关。这些结果表明，膀胱疼痛综合征/间质性膀胱炎可能不足。
Bladder pain syndrome/interstitial cystitis is a poorly understood condition that can cause serious disability. We provide the first population based symptom prevalence estimate to our knowledge among United States adult females. We developed and validated 2 case definitions to identify bladder pain syndrome/interstitial cystitis symptoms. Beginning in August 2007 we telephoned United States households, seeking adult women with bladder symptoms or a bladder pain syndrome/interstitial cystitis diagnosis. Second stage screening identified those subjects who met case definition criteria. Each completed a 60-minute interview on the severity and impact of bladder symptoms, health care seeking and demographics. Data collection ended in April 2009. Using population and nonresponse weights we calculated prevalence estimates based on definitions spanning a range of sensitivity and specificity. We used United States Census counts to estimate the number of affected women in 2006. The random sample included 146,231 households, of which 131,691 included an adult female. Of these households 32,474 reported an adult female with bladder symptoms or diagnosis, of which 12,752 completed the questionnaire. Based on the high sensitivity definition 6.53% (95% CI 6.28, 6.79) of women met symptom criteria. Based on the high specificity definition 2.70% (95% CI 2.53, 2.86) of women met the criteria. These percentages translated into 3.3 to 7.9 million United States women 18 years old or older with bladder pain syndrome/interstitial cystitis symptoms. Symptom severity and impact were comparable to those of adult women with established diagnoses. However, only 9.7% of the women reported being assigned a bladder pain syndrome/interstitial cystitis diagnosis. Bladder pain syndrome/interstitial cystitis symptoms are widespread among United States women and associated with considerable disability. These results suggest bladder pain syndrome/interstitial cystitis may be underdiagnosed.
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影响因子：
2.1
作者：
Lifford, Karen L.;Curhan, Gary C.
通讯作者：
Curhan, Gary C.
影响因子：
6.6
作者：
Clemens, JQ;Meenan, RT;Calhoun, EA
通讯作者：
Calhoun, EA
影响因子：
6.6
作者：
Leppilahti, M;Tammela, TLJ;Auvinen, A
通讯作者：
Auvinen, A
DOI：
10.1016/j.juro.2009.12.103
发表时间：
2010-05
期刊：
The Journal of urology
影响因子：
--
作者：
Berry SH;Bogart LM;Pham C;Liu K;Nyberg L;Stoto M;Suttorp M;Clemens JQ
通讯作者：
Clemens JQ
影响因子：
6.6
作者：
Curhan, GC;Speizer, FE;Stampfer, MJ
通讯作者：
Stampfer, MJ