Immunology of psoriasis.
Immunology of psoriasis.
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DOI：
10.1146/annurev-immunol-032713-120225
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发表时间：
2014
影响因子：
29.7
通讯作者：
Krueger JG
中科院分区：
文献类型：
--
作者：
Lowes MA;Suárez-Fariñas M;Krueger JG
皮肤是抵抗侮辱和伤害的前线，包含许多表皮和免疫成分，构成皮肤相关淋巴组织（SALT）。这些成分对损伤的反应允许有效的皮肤反应来恢复体内平衡。寻常型牛皮癣是最了解和最容易获得的由T细胞和树突状细胞介导的人类疾病。炎性骨髓树突状细胞释放IL-23和IL-12，激活产生IL-17的T细胞、Th1细胞和Th22细胞，产生丰富的银屑病细胞因子IL-17、IFN-γ、TNF和IL-22。这些细胞因子介导角质形成细胞的作用，放大银屑病炎症。抗细胞因子抗体的治疗研究表明关键细胞因子IL-23、TNF和IL-17在这一过程中的重要性。我们讨论牛皮癣的遗传背景及其与免疫功能的关系，特别是基因突变，关键psor位点，单核苷酸多态性和皮肤转录组。合并症和牛皮癣之间的关系是通过相关的皮肤转录组和血清蛋白进行审查。银屑病相关的细胞因子反应途径被认为是在不同小鼠模型的转录组的背景下。这种方法为其他炎症性皮肤和自身免疫性疾病提供了一种模型。
The skin is the front line of defense against insult and injury and contains many epidermal and immune elements that comprise the skin-associated lymphoid tissue (SALT). The reaction of these components to injury allows an effective cutaneous response to restore homeostasis. Psoriasis vulgaris is the best-understood and most accessible human disease that is mediated by T cells and dendritic cells. Inflammatory myeloid dendritic cells release IL-23 and IL-12 to activate IL-17-producing T cells, Th1 cells, and Th22 cells to produce abundant psoriatic cytokines IL-17, IFN-γ, TNF, and IL-22. These cytokines mediate effects on keratinocytes to amplify psoriatic inflammation. Therapeutic studies with anticytokine antibodies have shown the importance of the key cytokines IL-23, TNF, and IL-17 in this process. We discuss the genetic background of psoriasis and its relationship to immune function, specifically genetic mutations, key PSORS loci, single nucleotide polymorphisms, and the skin transcriptome. The association between comorbidities and psoriasis is reviewed by correlating the skin transcriptome and serum proteins. Psoriasis-related cytokine-response pathways are considered in the context of the transcriptome of different mouse models. This approach offers a model for other inflammatory skin and autoimmune diseases.
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影响因子：
7.4
作者：
Chamian F;Lin SL;Lee E;Kikuchi T;Gilleaudeau P;Sullivan-Whalen M;Cardinale I;Khatcherian A;Novitskaya I;Wittkowski KM;Krueger JG;Lowes MA
通讯作者：
Lowes MA
影响因子：
82.9
作者：
Conrad, Curdin;Boyman, Onur;Nestle, Frank O.
通讯作者：
Nestle, Frank O.
影响因子：
4.4
作者：
Angel, Catherine E.;George, Elizabeth;Dunbar, P. Rod
通讯作者：
Dunbar, P. Rod
影响因子：
3.1
作者：
Camporeale, Annalisa;Poli, Valeria
通讯作者：
Poli, Valeria
影响因子：
6.5
作者：
Crispin, Milene Kennedy;Fuentes-Duculan, Judilyn;Gulati, Nicholas;Johnson-Huang, Leanne M.;Lentini, Tim;Sullivan-Whalen, Mary;Gilleaudeau, Patricia;Cueto, Inna;Suarez-Farinas, Mayte;Lowes, Michelle A.;Krueger, James G.
通讯作者：
Krueger, James G.