Frequency of distinguishing clinical features in Vogt-Koyanagi-Harada disease.
Frequency of distinguishing clinical features in Vogt-Koyanagi-Harada disease.
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DOI：
10.1016/j.ophtha.2009.08.030
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发表时间：
2010-03
期刊：
影响因子：
13.7
通讯作者：
Read RW
中科院分区：
文献类型：
--
作者：
Rao NA;Gupta A;Dustin L;Chee SP;Okada AA;Khairallah M;Bodaghi B;Lehoang P;Accorinti M;Mochizuki M;Prabriputaloong T;Read RW
确定Vogt-Koyanagi-Harada(VKH)病患者与非VKH葡萄膜炎患者有限临床特征的出现频率。比较案例系列。患者总数1147人。在2006-01-01和2006-03-31(含)期间的三个月期间，所有在10个葡萄膜炎中心就诊的双眼炎症性疾病患者被要求参加研究。通过直接访谈和查阅图表，从参与者那里获得疾病的临床和历史特征。患者根据他们是否被诊断为VKH病或非VKH葡萄膜炎进行分层以进行统计分析。在这两个人群中是否存在各种临床特征。在1147例患者中，180例被诊断为VKH病，967例为非VKH葡萄膜炎。与其他种族相比，西班牙裔和亚洲人更有可能被诊断为VKH，而不是非VKH疾病。在急性疾病中，渗出性视网膜脱离最有可能出现在VKH病中，阳性预测值(PPV)为100，阴性预测值(NPV)为88.4；在慢性病中，最容易发现日落辉光眼底，PPV为94.5，NPV为89.2。过去，许多临床表现被描述为诊断VKH的重要依据。目前的研究表明，在种族和地理上不同的非创伤性双眼葡萄膜炎患者组中，有两个是高度特异的。这些临床表现是：1.急性期渗出性视网膜脱离；2.慢性期日落辉光眼底。
To determine the frequency of occurrence of limited clinical features which distinguish patients with Vogt-Koyanagi-Harada (VKH) disease from those with non-VKH uveitis. Comparative case series. 1147 total patients. All patients with bilateral ocular inflammatory disease presenting to any of ten uveitis centers in the three month period between 2006-January-01 and 2006-March-31 (inclusive) were asked to participate. The clinical and historical features of disease were obtained from the participants via direct interview and chart review. Patients were stratified based on whether they were diagnosed with VKH disease or non-VKH uveitis for statistical analysis. Presence or absence of various clinical features in the two populations. Of 1147 patients, 180 were diagnosed with VKH disease and 967 with non-VKH uveitis. Hispanics and Asians were more likely to be diagnosed with VKH than non-VKH disease compared to other ethnicities. In acute disease, the finding of exudative retinal detachment was most likely to be found in VKH disease with a positive predictive value (PPV) of 100 and negative predictive value (NPV) of 88.4, while in chronic disease, sunset glow fundus was most likely to be found, with a PPV of 94.5 and NPV of 89.2. Numerous clinical findings have been described in the past as important in the diagnosis of VKH. The current study reveals that of these, two are highly specific to this entity in an ethnically and geographically diverse group of patients with non-traumatic bilateral uveitis. These clinical findings are 1. exudative retinal detachment during acute disease and 2. sunset glow fundus during the chronic phase of the disease.
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影响因子：
--
作者：
FORSTER, DJ;CANO, MR;RAO, NA
通讯作者：
RAO, NA
影响因子：
4.2
作者：
Inomata, H;Rao, NA
通讯作者：
Rao, NA
影响因子：
13.7
作者：
Yang, Peizeng;Ren, Yalin;Kijlstra, Aize
通讯作者：
Kijlstra, Aize
影响因子：
--
作者：
RUBSAMEN, PE;GASS, JDM
通讯作者：
GASS, JDM
影响因子：
1.6
作者：
Tsai, Julie H.;Sukavatcharin, Somsiri;Rao, Narsing A.
通讯作者：
Rao, Narsing A.