Prenatal TCDD in mice increases adult autoimmunity.
Prenatal TCDD in mice increases adult autoimmunity.
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DOI：
10.1016/j.reprotox.2010.08.001
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Gogal RM Jr
中科院分区：
文献类型：
--
作者：
Holladay SD;Mustafa A;Gogal RM Jr
两种免疫学不同的小鼠品系，C57 BL/6和SNF 1，暴露于妊娠中期剂量的TCDD。C57 BL/6小鼠具有高亲和力的芳烃受体（AhR），对TCDD敏感。SNF 1小鼠具有低亲和力AhR，但自发地发展自身免疫性肾炎。C57 BL/6小鼠后代24周龄时，自身反应性Vβ+ CD 4 + 17 a和Vβ+ CD 3 + T细胞增加，雌性小鼠的增加幅度大于雄性小鼠。雌性动物中细胞因子IFN-γ升高，而雄性动物中IL-10升高。产前TCDD后，骨髓和脾脏中B系细胞的表型改变，循环自身抗体增加。男性肾脏显示显著的抗IgG和抗C3沉积，提示早期自身免疫性疾病。SNF 1后代同样显示雌性外周Vβ+细胞增加，两种性别的自身抗体产生增加，雌性IFN-γ产生增加。雄性SNF 1小鼠肾脏中抗IgG和抗C3沉积增加。因此，两种小鼠模型均显示出产前TCDD后自身免疫增强的明确特征。
Two immunologically-different mouse strains, C57BL/6 and SNF1, were exposed to a mid-gestation dose of TCDD. The C57BL/6 mouse has a high-affinity aryl hydrocarbon receptor (AhR) and is sensitive to TCDD. The SNF1 mouse has a low-affinity AhR but spontaneously develops autoimmune nephritis. Autoreactive Vβ+CD4+17a and Vβ+CD3+ T cells were increased at 24-weeks-of-age in offspring of C57BL/6 mice, more so in females than males. The cytokine IFN-γ was elevated in the females, while IL-10 was elevated in males. Phenotypic changes in B-lineage cells were present in bone marrow and spleen, and circulating autoantibodies were increased after prenatal TCDD. Kidneys of males showed significant anti-IgG and anti-C3 deposition, suggesting early-stage autoimmune disease. The SNF1 offspring similarly showed increased peripheral Vβ+ cells in the females, increased autoantibody production in both sexes, and increased IFN-γ production in females. Male SNF1 mice had increased anti-IgG and anti-C3 deposition in kidneys. Both mouse models therefore showed clear signatures of enhanced autoimmunity after prenatal TCDD.
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DOI：
10.1002/bdra.20603
发表时间：
2009-10
影响因子：
--
作者：
Mustafa, Amjad;Holladay, Steven D.;Goff, Matthew;Witonsky, Sharon;Kerr, Richard;Weinstein, Danielle A.;Karpuzoglu-Belgin, Ebru;Gogal, Robert M., Jr.
通讯作者：
Gogal, Robert M., Jr.
DOI：
10.1080/15287397709529578
发表时间：
1977-01-01
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH
影响因子：
--
作者：
FAITH, RE;MOORE, JA
通讯作者：
MOORE, JA
影响因子：
3.8
作者：
Mustafa, Amjad;Holladay, Steven D.;Gogal, Robert M., Jr.
通讯作者：
Gogal, Robert M., Jr.
影响因子：
4.6
作者：
Wang, Y.;Ito, S.;Sumida, T.
通讯作者：
Sumida, T.
影响因子：
3.8
作者：
GREENLEE, WF;DOLD, KM;OSBORNE, R
通讯作者：
OSBORNE, R