Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk.
Recreational Physical Activity and Outcomes After Breast Cancer in Women at High Familial Risk.
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DOI：
10.1093/jncics/pkab090
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发表时间：
2021-12
影响因子：
4.4
通讯作者：
Terry MB
中科院分区：
文献类型：
--
作者：
Kehm RD;MacInnis RJ;John EM;Liao Y;Kurian AW;Genkinger JM;Knight JA;Colonna SV;Chung WK;Milne R;Zeinomar N;Dite GS;Southey MC;Giles GG;McLachlan SA;Whitaker KD;Friedlander ML;Weideman PC;Glendon G;Nesci S;kConFab Investigators;Phillips KA;Andrulis IL;Buys SS;Daly MB;Hopper JL;Terry MB
Recreational physical activity (RPA) is associated with improved survival after breast cancer (BC) in average-risk women, but evidence is limited for women who are at increased familial risk because of a BC family history or BRCA1 and BRCA2 pathogenic variants (BRCA1/2 PVs). We estimated associations of RPA (self-reported average hours per week within 3 years of BC diagnosis) with all-cause mortality and second BC events (recurrence or new primary) after first invasive BC in women in the Prospective Family Study Cohort (n = 4610, diagnosed 1993-2011, aged 22-79 years at diagnosis). We fitted Cox proportional hazards regression models adjusted for age at diagnosis, demographics, and lifestyle factors. We tested for multiplicative interactions (Wald test statistic for cross-product terms) and additive interactions (relative excess risk due to interaction) by age at diagnosis, body mass index, estrogen receptor status, stage at diagnosis, BRCA1/2 PVs, and familial risk score estimated from multigenerational pedigree data. Statistical tests were 2-sided. We observed 1212 deaths and 473 second BC events over a median follow-up from study enrollment of 11.0 and 10.5 years, respectively. After adjusting for covariates, RPA (any vs none) was associated with lower all-cause mortality of 16.1% (95% confidence interval [CI] = 2.4% to 27.9%) overall, 11.8% (95% CI = -3.6% to 24.9%) in women without BRCA1/2 PVs, and 47.5% (95% CI = 17.4% to 66.6%) in women with BRCA1/2 PVs (RPA*BRCA1/2 multiplicative interaction P = .005; relative excess risk due to interaction = 0.87, 95% CI = 0.01 to 1.74). RPA was not associated with risk of second BC events. Findings support that RPA is associated with lower all-cause mortality in women with BC, particularly in women with BRCA1/2 PVs.
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影响因子：
3.8
作者：
Keegan, Theresa H. M.;Milne, Roger L.;Andrulis, Irene L.;Chang, Ellen T.;Sangaramoorthy, Meera;Phillips, Kelly-Anne;Giles, Graham G.;Goodwin, Pamela J.;Apicella, Carmel;Hopper, John L.;Whittemore, Alice S.;John, Esther M.
通讯作者：
John, Esther M.
BRCA1和BRCA2在双链断裂修复中的不同功能。
DOI：
10.1186/bcr417
发表时间：
2002
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Liu Y;West SC
通讯作者：
West SC
影响因子：
8.4
作者：
Derks, M. G. M.;Bastiaannet, E.;Liefers, G. J.
通讯作者：
Liefers, G. J.
影响因子：
3.8
作者：
Cheng, Lee;Swartz, Michael D.;Giordano, Sharon H.
通讯作者：
Giordano, Sharon H.
影响因子：
8.8
作者：
Antoniou, A. C.;Cunningham, A. P.;Peto, J.;Evans, D. G.;Lalloo, F.;Narod, S. A.;Risch, H. A.;Eyfjord, J. E.;Hopper, J. L.;Southey, M. C.;Olsson, H.;Johannsson, O.;Borg, A.;Passini, B.;Radice, P.;Manoukian, S.;Eccles, D. M.;Tang, N.;Olah, E.;Anton-Culver, H.;Warner, E.;Lubinski, J.;Gronwald, J.;Gorski, B.;Tryggvadottir, L.;Syrjakoski, K.;Kallioniemi, O-P;Eerola, H.;Nevanlinna, H.;Pharoah, P. D. P.;Easton, D. F.
通讯作者：
Easton, D. F.