Past recreational physical activity, body size, and all-cause mortality following breast cancer diagnosis: results from the Breast Cancer Family Registry.
Past recreational physical activity, body size, and all-cause mortality following breast cancer diagnosis: results from the Breast Cancer Family Registry.
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DOI：
10.1007/s10549-010-0774-6
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发表时间：
2010-09
影响因子：
3.8
通讯作者：
John, Esther M.
中科院分区：
文献类型：
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作者：
Keegan, Theresa H. M.;Milne, Roger L.;Andrulis, Irene L.;Chang, Ellen T.;Sangaramoorthy, Meera;Phillips, Kelly-Anne;Giles, Graham G.;Goodwin, Pamela J.;Apicella, Carmel;Hopper, John L.;Whittemore, Alice S.;John, Esther M.
很少有研究考虑体重指数(BMI)和体力活动这两个可改变的因素与乳腺癌诊断后全因死亡率的联合关系。1991年至2000年间被诊断为浸润性乳腺癌(n=4153)的妇女通过基于人口的抽样在美国北加州、加拿大安大略省以及澳大利亚墨尔本和悉尼的乳腺癌家庭登记处登记。在平均7.8年的随访期间，发生了725例死亡。基线问卷在诊断前评估了中等强度和剧烈的娱乐体育活动和BMI。通过COX比例风险回归，对已确定的预后因素进行调整，评估与全因死亡率的相关性。与没有体力活动相比，确诊前三年内任何娱乐活动与患有雌激素受体(ER)阳性肿瘤的女性的死亡风险降低34%(风险比(HR)=0.66，95%可信区间(CI)：0.51-0.85)相关；这种关联似乎没有种族/民族或BMI的差异。终生体力活动与全因死亡率无关。体重指数与50岁≥诊断为ER阳性肿瘤的女性的全因死亡率呈正相关(与正常体重女性相比，超重的HR=1.39，95%CI：0.90~2.15；肥胖的HR=1.77，95%CI：1.11~2.82)。体重指数相关性似乎并不因种族/民族而异。我们的发现表明，体力活动和BMI对乳腺癌后的总死亡率有独立的影响。
Few studies have considered the joint association of body mass index (BMI) and physical activity, two modifiable factors, with all-cause mortality after breast cancer diagnosis. Women diagnosed with invasive breast cancer (n=4,153) between 1991 and 2000 were enrolled in the Breast Cancer Family Registry through population-based sampling in Northern California, USA; Ontario, Canada; and Melbourne and Sydney, Australia. During a median follow-up of 7.8 years, 725 deaths occurred. Baseline questionnaires assessed moderate and vigorous recreational physical activity and BMI prior to diagnosis. Associations with all-cause mortality were assessed using Cox proportional hazards regression, adjusting for established prognostic factors. Compared with no physical activity, any recreational activity during the three years prior to diagnosis was associated with a 34% lower risk of death (hazard ratio (HR) = 0.66, 95% confidence interval (CI): 0.51-0.85) for women with estrogen receptor (ER)-positive tumors, but not those with ER-negative tumors; this association did not appear to differ by race/ethnicity or BMI. Lifetime physical activity was not associated with all-cause mortality. BMI was positively associated with all-cause mortality for women diagnosed at age ≥50 years with ER-positive tumors (compared with normal-weight women, HR for overweight = 1.39, 95% CI: 0.90-2.15; HR for obese = 1.77, 95% CI: 1.11-2.82). BMI associations did not appear to differ by race/ethnicity. Our findings suggest that physical activity and BMI exert independent effects on overall mortality after breast cancer.
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影响因子：
6.4
作者：
Dal Maso, Luigino;Zucchetto, Antonella;Franceschi, Silvia
通讯作者：
Franceschi, Silvia
影响因子：
50.5
作者：
Berclaz, G;Li, S;International Breast Cancer Study Grp
通讯作者：
International Breast Cancer Study Grp
影响因子：
45.3
作者：
Goodwin, PJ;Ennis, M;Hood, N
通讯作者：
Hood, N
影响因子：
6.2
作者：
Abrahamson, Page E.;Gammon, Marilie D.;Coates, Ralph J.
通讯作者：
Coates, Ralph J.
影响因子：
8.8
作者：
通讯作者：
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