The scientific exploration of saliva in the post-proteomic era: from database back to basic function.
The scientific exploration of saliva in the post-proteomic era: from database back to basic function.
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DOI：
10.1586/epr.11.80
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发表时间：
2012
影响因子：
3.4
通讯作者：
Ruhl S
中科院分区：
文献类型：
--
作者：
Ruhl S
人类唾液的蛋白质组可以被认为是基本上完成的。利用唾液作为易于获得的生物液体的优势，已在唾液蛋白和肽中确定了许多疾病的诊断标记物。然而，迄今为止确定的大多数疾病标志物是血清成分，而不是唾液腺产生的内在蛋白质。此外，尽管事实上，唾液是必不可少的保护口腔覆盖物和牙列，已经取得了很小的进展，在寻找龋齿或牙周病的唾液蛋白质组的风险预测。由于唾液蛋白，特别是附着的聚糖，在与微生物世界的相互作用中发挥重要作用，唾液糖蛋白组和唾液蛋白的其他翻译后修饰需要研究。包括龋齿在内的微生物疾病的风险标志物很可能在唾液中高度糖基化的主要蛋白质种类中发现。这篇综述将试图提出新的想法，并指出研究不足的领域，可能持有的承诺，未来适用于口腔诊断和口腔疾病的预测。
The proteome of human saliva can be considered as being essentially completed. Diagnostic markers for a number of diseases have been identified among salivary proteins and peptides, taking advantage of saliva as an easy-to-obtain biological fluid. Yet, the majority of disease markers identified so far are serum components and not intrinsic proteins produced by the salivary glands. Furthermore, despite the fact that saliva is essential for protecting the oral integuments and dentition, little progress has been made in finding risk predictors in the salivary proteome for dental caries or periodontal disease. Since salivary proteins, and in particular the attached glycans, play an important role in interactions with the microbial world, the salivary glycoproteome and other post-translational modifications of salivary proteins need to be studied. Risk markers for microbial diseases, including dental caries, are likely to be discovered among the highly glycosylated major protein species in saliva. This review will attempt to raise new ideas and also point to under-researched areas that may hold promise for future applicability in oral diagnostics and prediction of oral disease.
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影响因子：
4.4
作者：
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通讯作者：
Yates, John R., III
影响因子：
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作者：
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通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
7.6
作者：
Emmings, FG
通讯作者：
Emmings, FG
影响因子：
7.4
作者：
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通讯作者：
Walt, David R.