Interleukin-15 biology and its therapeutic implications in cancer.
Interleukin-15 biology and its therapeutic implications in cancer.
复制标题
白介素15生物学及其在癌症中的治疗意义。
DOI：
10.1016/j.tips.2011.09.004
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发表时间：
2012-01
影响因子：
13.8
通讯作者：
Morris JC
中科院分区：
文献类型：
--
作者：
Steel JC;Waldmann TA;Morris JC
癌症免疫疗法旨在刺激免疫系统排斥和摧毁肿瘤。最近，白细胞介素-15（IL-15），细胞因子的4-α-螺旋束家族的成员，已经成为用于治疗癌症的候选免疫调节剂。IL-15通过其特异性受体IL-15 R α发挥作用，IL-15 R α在抗原呈递树突状细胞、单核细胞和巨噬细胞上表达。IL-15表现出广泛的活性并诱导T、B和自然杀伤（NK）细胞的分化和增殖。它还增强CD 8 + T细胞的细胞溶解活性，并诱导持久的抗原经历的CD 8 + CD 44 hi记忆T细胞。IL-15刺激B细胞的分化和免疫球蛋白合成，并诱导树突状细胞的成熟。它不刺激免疫抑制性调节性T细胞（T细胞）。因此，提高IL-15活性可以增强先天和特异性免疫并对抗肿瘤。在这里，我们回顾了IL-15生物学方面，使其成为一个有前途的抗癌治疗剂。我们还讨论了IL-15已被证明具有抗肿瘤活性的临床前模型，并强调了IL-15在癌症和HIV感染患者中正在进行的临床试验。
Cancer immunotherapy is designed to stimulate the immune system to reject and destroy tumors. Recently, interleukin-15 (IL-15), a member of the 4-alpha-helix bundle family of cytokines, has emerged as a candidate immunomodulator for the treatment of cancer. IL-15 acts through its specific receptor, IL-15Rα, which is expressed on antigen-presenting dendritic cells, monocytes and macrophages. IL-15 exhibits broad activity and induces the differentiation and proliferation of T, B and natural killer (NK) cells. It also enhances cytolytic activity of CD8+ T cells and induces long-lasting antigen-experienced CD8+CD44hi memory T cells. IL-15 stimulates differentiation and immunoglobulin synthesis by B cells and induces maturation of dendritic cells. It does not stimulate immunosuppressive T regulatory cells (Tregs). Thus, boosting IL-15 activity could enhance innate and specific immunity and fight tumors. Here we review aspects of IL-15 biology that make it a promising agent for anticancer therapy. We also discuss preclinical models in which IL-15 has demonstrated antitumor activity and highlight ongoing clinical trials of IL-15 in patients with cancer and HIV infection.
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DOI：
10.1056/nejmoa1003466
发表时间：
2010-08-19
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hodi FS;O'Day SJ;McDermott DF;Weber RW;Sosman JA;Haanen JB;Gonzalez R;Robert C;Schadendorf D;Hassel JC;Akerley W;van den Eertwegh AJ;Lutzky J;Lorigan P;Vaubel JM;Linette GP;Hogg D;Ottensmeier CH;Lebbé C;Peschel C;Quirt I;Clark JI;Wolchok JD;Weber JS;Tian J;Yellin MJ;Nichol GM;Hoos A;Urba WJ
通讯作者：
Urba WJ
影响因子：
11.4
作者：
GIRI, JG;KUMAKI, S;ANDERSON, DM
通讯作者：
ANDERSON, DM
影响因子：
56.9
作者：
GRABSTEIN, KH;EISENMAN, J;GIRI, JG
通讯作者：
GIRI, JG
影响因子：
158.5
作者：
Kantoff, Philip W.;Higano, Celestia S.;Young, J.
通讯作者：
Young, J.
DOI：
10.1084/jem.191.5.771
发表时间：
2000-03-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kennedy MK;Glaccum M;Brown SN;Butz EA;Viney JL;Embers M;Matsuki N;Charrier K;Sedger L;Willis CR;Brasel K;Morrissey PJ;Stocking K;Schuh JC;Joyce S;Peschon JJ
通讯作者：
Peschon JJ