Association between lymphocyte and monocyte subsets and cognition in children with HIV.
Association between lymphocyte and monocyte subsets and cognition in children with HIV.
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DOI：
10.1186/1742-6405-11-7
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发表时间：
2014-01-22
影响因子：
2.2
通讯作者：
PREDICT Study Group
中科院分区：
文献类型：
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作者：
Ananworanich J;Bunupuradah T;Apornpong T;Kosalaraksa P;Hansudewechakul R;Kanjanavanit S;Ngampiyaskul C;Wongsawat J;Luesomboon W;Ngo-Giang-Huong N;Jaimulwong T;Kerr SJ;Brouwers P;Shearer WT;Puthanakit T;PREDICT Study Group
本研究评估了淋巴细胞和单核细胞亚群与智商（IQ）分数之间的关系，在抗逆转录病毒治疗（ART）初治，艾滋病毒感染的泰国儿童没有先进的艾滋病毒疾病。67名CD 4在15-24%之间的ART初治泰国儿童接受了Weschler智力量表的认知测试，并通过流式细胞术进行了13个细胞亚群的测试，包括CD 4+和CD 8 + T细胞的幼稚、记忆和活化亚群，活化和血管周围单核细胞以及B细胞。使用log 10细胞计数和细胞百分比转换进行回归建模。中位年龄（IQR）为9（7-10）岁，33%为男性，CDC分期N：A：B为1：67：31%，中位CD 4%和计数（IQR）为21（18-24）%，597（424-801）个细胞/mm 3，HIV RNA（IQR）为4.6（4.1-4.9）log 10拷贝/ml。大多数人（82%）住在家里，45%的人有亲生父母作为他们的主要照顾者，26人（49%）家庭收入低。全量表智商（FIQ）的平均（SD）得分为75（13），言语智商（VIQ）为73（12），操作智商（PIQ）为80（14）。调整后的多变量回归分析显示，B细胞计数与FIQ、VIQ和PIQ之间存在显著的负相关性（均为p < 0.01）; B细胞百分比也存在类似的相关性（均为p < 0.05）。高B细胞计数和百分比与较差的FIQ、VIQ和PIQ评分密切相关。前瞻性、长期的细胞亚群评估和相关B细胞亚群的测定有助于进一步阐明淋巴细胞亚群与神经认知发育之间的关联。
This study assesses the relationships between lymphocyte and monocyte subsets and intelligence quotient (IQ) scores in antiretroviral therapy (ART)-naive, HIV-infected Thai children without advanced HIV disease. Sixty-seven ART-naive Thai children with CD4 between 15-24% underwent cognitive testing by Weschler intelligence scale and had 13 cell subsets performed by flow cytometry including naive, memory and activated subsets of CD4+ and CD8+ T cells, activated and perivascular monocytes and B cells. Regression modelling with log10 cell count and cell percentage transformation was performed. Median age (IQR) was 9 (7–10) years, 33% were male, CDC stages N:A:B were 1:67:31%, median CD4% and count (IQR) were 21 (18–24)%, 597 (424–801) cells/mm3 and HIV RNA (IQR) was 4.6 (4.1-4.9) log10 copies/ml. Most (82%) lived at home, 45% had a biological parent as their primary caregiver, and 26 (49%) had low family income. The mean (SD) scores were 75 (13) for full scale IQ (FIQ), 73 (12) for verbal IQ (VIQ) and 80 (14) for performance IQ (PIQ). Adjusted multivariate regression analysis showed significant negative associations between B cell counts and FIQ, VIQ and PIQ (p < 0.01 for all); similar associations were found for B cell percentages (p < 0.05 for all). High B cell counts and percentages were strongly associated with poorer FIQ, VIQ and PIQ scores. Prospective, long-term assessment of cell subsets and determination of relevant B cell subpopulations could help further elucidate associations between lymphocyte subsets and neurocognitive development.
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影响因子：
3.2
作者：
Fischer-Smith T;Bell C;Croul S;Lewis M;Rappaport J
通讯作者：
Rappaport J
影响因子：
14.2
作者：
Ananworanich, Jintanat;Apornpong, Tanakorn;Shearer, William T.
通讯作者：
Shearer, William T.
影响因子：
3.7
作者：
Ashwood P;Corbett BA;Kantor A;Schulman H;Van de Water J;Amaral DG
通讯作者：
Amaral DG
DOI：
10.1097/inf.0b013e31827fb19d
发表时间：
2013-05
期刊：
The Pediatric infectious disease journal
影响因子：
--
作者：
Puthanakit T;Ananworanich J;Vonthanak S;Kosalaraksa P;Hansudewechakul R;van der Lugt J;Kerr SJ;Kanjanavanit S;Ngampiyaskul C;Wongsawat J;Luesomboon W;Vibol U;Pruksakaew K;Suwarnlerk T;Apornpong T;Ratanadilok K;Paul R;Mofenson LM;Fox L;Valcour V;Brouwers P;Ruxrungtham K;PREDICT Study Group
通讯作者：
PREDICT Study Group
DOI：
10.1097/qad.0b013e328352cee7
发表时间：
2012-05-15
期刊：
AIDS (London, England)
影响因子：
--
作者：
Kapetanovic S;Aaron L;Montepiedra G;Burchett SK;Kovacs A
通讯作者：
Kovacs A