Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth.
Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth.
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DOI：
10.1111/j.1399-5448.2010.00705.x
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发表时间：
2011-05
影响因子：
3.4
通讯作者：
Arslanian SA
中科院分区：
文献类型：
--
作者：
Lee S;Kuk JL;Kim Y;Arslanian SA
目前尚不清楚内脏脂肪组织（VAT）的测量部位是否影响VAT与青年相关健康风险之间的关系，如果是这样，这种关系是否存在种族差异。我们研究了非裔美国人（AA）和美国白人（AW）青年中VAT测量部位对VAT和代谢综合征（MetS）之间关系的影响。健康AA（n = 54）和AW（n = 54）儿童和青少年（年龄：8-18岁; BMI：15.3-42.5 kg/m2）。通过磁共振成像测量的一系列五个横向图像得出VAT质量，从L4-L5以下5 cm延伸到L4-L5以上15 cm。MetS使用修改的IDF标准定义。在AA中，L4-L5上方5 cm处的VAT测量值（R2 = 0.93）与VAT质量的相关性最强（p <0.05），并且与L4-L5（R2 = 0.84）相比，相关性显著（p < 0.05）更强。在AW中，L4-L5上方5 cm（R2 = 0.93）和10 cm（R2 = 0.93）处的VAT测量值与VAT质量的相关性最强（p < 0.05）;然而，与L4-L5（R2 = 0.91）相比，这些相关性并不强。在AW中，所有VAT指标均与普遍MetS的比值比（OR）增加显著相关（p < 0.05），其中VAT质量[OR = 5.32（1.9-15.0）]和L4-L5的VAT [OR = 5.99（1.9-18.4）]与MetS的相关性最强。相比之下，只有L4-L5上方10 cm处的VAT [OR = 4.39（1.1-18.1）]与AA中的MetS显著相关（p < 0.05）。在AA和AW青年中，VAT的测量部位对总VAT的估计以及与肥胖相关健康风险的关联程度有影响。
It is unknown whether measurement site of visceral adipose tissue (VAT) influences the relationship between VAT and associated health risk in youth and if so, whether ethnic differences exist in this relationship. We examined the influence of the measurement site of VAT on the relationships between VAT and metabolic syndrome (MetS) in African-American (AA) and American-White (AW) youth. Healthy AA (n = 54) and AW (n = 54) children and adolescents (age: 8–18 yr; BMI: 15.3–42.5 kg/m2). VAT mass was derived using a series of five transverse images measured by magnetic resonance imaging, extending from 5 cm below to 15 cm above L4-L5. MetS was defined using a modified IDF criteria. In AA, VAT measure at 5 cm above L4-L5 (R2 = 0.93) was most strongly (p < 0.05) correlated with VAT mass and was a significantly (p < 0.05) stronger correlate as compared to L4-L5 (R2 = 0.84). In AW, VAT measures at 5 cm (R2 = 0.93) and 10 cm (R2 = 0.93) above L4-L5 were most strongly (p < 0.05) correlated with VAT mass; however, these were not stronger correlates as compared to L4-L5 (R2 = 0.91). In AW, all VAT measures were significantly (p < 0.05) associated with an increased odds ratio (OR) for prevalent MetS, wherein the VAT mass [OR = 5.32(1.9–15.0)] and VAT at L4-L5 [OR = 5.99(1.9–18.4)] were most strongly associated with MetS. In contrast, only VAT at 10 cm above L4-L5 [OR = 4.39 (1.1–18.1)] was significantly (p < 0.05) associated with MetS in AA. In AA and AW youth, the measurement site for VAT has impact on the estimation of total VAT and the magnitude of the association with obesity-related health risks.
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影响因子：
5.1
作者：
Lee, Sojung;Bacha, Fida;Arslanian, Silva A.
通讯作者：
Arslanian, Silva A.
影响因子：
3.3
作者：
Ross, R;Rissanen, J;Shragge, P
通讯作者：
Shragge, P
影响因子：
168.9
作者：
Weiss, R;Dufour, S;Caprio, S
通讯作者：
Caprio, S
影响因子：
16.2
作者：
Kuk, JL;Church, TS;Ross, R
通讯作者：
Ross, R
影响因子：
3.3
作者：
Lee, S;Janssen, I;Ross, R
通讯作者：
Ross, R