The cryptic sexual strategies of human fungal pathogens.

The cryptic sexual strategies of human fungal pathogens.
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DOI:
10.1038/nrmicro3236
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发表时间:
2014-04
期刊:
Nature reviews. Microbiology
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其他
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有性繁殖是真核物种的普遍属性,现在被认为发生在许多临床上重要的人类真菌病原体中。这些真菌使用有性或准有性策略来达到各种目的,这些目的可能对发病机制产生影响,例如耐药菌株的形成、毒力增加的菌株的产生或与宿主细胞相互作用的调节。在这篇综述中,我们研究了调节真菌性的机制以及这些项目对人类疾病的影响。
Sexual reproduction is a pervasive attribute of eukaryotic species and is now recognized to occur in many clinically important human fungal pathogens. These fungi use sexual or parasexual strategies for various purposes that can have an impact on pathogenesis, such as the formation of drug-resistant isolates, the generation of strains with increased virulence or the modulation of interactions with host cells. In this Review, we examine the mechanisms regulating fungal sex and the consequences of these programmes for human disease.
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