Aquaporins: New players in breast cancer progression and treatment response.
Aquaporins: New players in breast cancer progression and treatment response.
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水通道蛋白：乳腺癌进展和治疗反应的新参与者。
DOI：
10.3389/fonc.2022.988119
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发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
水通道蛋白（Aquaporins，AQP）是一类跨膜小分子蛋白，它能选择性地将水和其它小分子离子通过渗透压梯度转运到细胞质膜上。这使它们能够调节许多功能，包括水稳态，脂肪代谢，增殖，迁移和粘附。以前的结构和功能研究强调了AQP蛋白表达，定位和正常和癌症组织中的关键生物学功能之间的强生物学关系，其中异常AQP表达与肿瘤发生和转移相关。在这篇综述中，我们讨论了AQP1，AQP3，AQP4，AQP5和AQP7在乳腺癌进展和转移中的作用，包括AQPs在肿瘤微环境中的作用，以突出基质来源的上皮来源的AQPs对乳腺癌的潜在贡献。新出现的证据将AQP确定为癌症治疗反应的预测因子，并作为增加其治疗敏感性的靶点。然而，这些研究尚未评估乳腺癌背景下AQP功能对蛋白质结构的要求。我们还研究了AQP如何有助于患者对癌症治疗的反应，现有的AQP抑制剂以及AQP如何作为乳腺癌治疗反应的新型预测生物标志物。未来的研究还应评估AQP冗余和补偿机制，用于克服AQP功能异常。这篇综述强调了需要进一步研究水通道蛋白如何在分子上对治疗耐药性做出贡献，并通过改变肿瘤微环境。
Aquaporins (AQPs) are a family of small transmembrane proteins that selectively transport water and other small molecules and ions following an osmotic gradient across cell plasma membranes. This enables them to regulate numerous functions including water homeostasis, fat metabolism, proliferation, migration, and adhesion. Previous structural and functional studies highlight a strong biological relationship between AQP protein expression, localization, and key biological functions in normal and cancer tissues, where aberrant AQP expression correlates with tumorigenesis and metastasis. In this review, we discuss the roles of AQP1, AQP3, AQP4, AQP5, and AQP7 in breast cancer progression and metastasis, including the role of AQPs in the tumor microenvironment, to highlight potential contributions of stromal-derived to epithelial-derived AQPs to breast cancer. Emerging evidence identifies AQPs as predictors of response to cancer therapy and as targets for increasing their sensitivity to treatment. However, these studies have not evaluated the requirements for protein structure on AQP function within the context of breast cancer. We also examine how AQPs contribute to a patient’s response to cancer treatment, existing AQP inhibitors and how AQPs could serve as novel predictive biomarkers of therapy response in breast cancer. Future studies also should evaluate AQP redundancy and compensation as mechanisms used to overcome aberrant AQP function. This review highlights the need for additional research into how AQPs contribute molecularly to therapeutic resistance and by altering the tumor microenvironment.
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影响因子：
5.6
作者：
da Silva, Ines Vieira;Diaz-Saez, Francisco;Soveral, Graca
通讯作者：
Soveral, Graca
影响因子：
11.2
作者：
Dai C;Charlestin V;Wang M;Walker ZT;Miranda-Vergara MC;Facchine BA;Wu J;Kaliney WJ;Dovichi NJ;Li J;Littlepage LE
通讯作者：
Littlepage LE
DOI：
10.3390/diagnostics11030452
发表时间：
2021-03-05
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Angelico G;Ieni A;Caltabiano R;Santoro A;Inzani F;Spadola S;Tuccari G;Macrì A;Zannoni GF
通讯作者：
Zannoni GF
影响因子：
4
作者：
Calamita G;Perret J;Delporte C
通讯作者：
Delporte C
DOI：
10.1073/pnas.0507225103
发表时间：
2006-01-10
影响因子：
11.1
作者：
Beitz, E;Wu, BH;Zeuthen, T
通讯作者：
Zeuthen, T