Urinary and dietary analysis of 18,470 bangladeshis reveal a correlation of rice consumption with arsenic exposure and toxicity.
Urinary and dietary analysis of 18,470 bangladeshis reveal a correlation of rice consumption with arsenic exposure and toxicity.
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DOI：
10.1371/journal.pone.0080691
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ahsan H
中科院分区：
文献类型：
--
作者：
Melkonian S;Argos M;Hall MN;Chen Y;Parvez F;Pierce B;Cao H;Aschebrook-Kilfoy B;Ahmed A;Islam T;Slavcovich V;Gamble M;Haris PI;Graziano JH;Ahsan H
我们利用来自孟加拉国Araihazar的砷对健康影响纵向研究（HEALS）的数据，在整个研究队列（N= 18，470）和具有可用尿砷代谢物数据的子集（N= 4，517）中评估蒸米饭消费与尿总砷浓度和砷性皮肤病变的关联。一般的线性模型与标准化的β系数被用来估计蒸米饭的消费和尿总砷浓度和尿砷代谢产物之间的关联。Logistic回归模型用于估计患病率比值比（OR）及其95%置信区间（CI），以了解大米摄入量与基线时皮肤病变患病率之间的关系。离散时间风险模型被用来估计离散时间（HRs）的比率和95%CI之间的关联大米摄入量和事件的皮肤病变。在模型中，米饭摄入量与肌酐校正的尿总砷呈正相关（β=0.041，95% CI：0.032-0.051），与肌酐统计校正的尿总砷呈正相关（β=0.043，95% CI：0.032-0.053）。此外，我们观察到与米饭摄入量增加相关的皮肤病变患病率的显著趋势（P趋势=0.007）和皮肤病变发病率的中度趋势（P趋势=0.07）。这项研究表明，大米摄入量可能是一个来源的砷暴露超过饮用水。
We utilized data from the Health Effects of Arsenic Longitudinal Study (HEALS) in Araihazar, Bangladesh, to evaluate the association of steamed rice consumption with urinary total arsenic concentration and arsenical skin lesions in the overall study cohort (N=18,470) and in a subset with available urinary arsenic metabolite data (N=4,517). General linear models with standardized beta coefficients were used to estimate associations between steamed rice consumption and urinary total arsenic concentration and urinary arsenic metabolites. Logistic regression models were used to estimate prevalence odds ratios (ORs) and their 95% confidence intervals (CIs) for the associations between rice intake and prevalent skin lesions at baseline. Discrete time hazard models were used to estimate discrete time (HRs) ratios and their 95% CIs for the associations between rice intake and incident skin lesions. Steamed rice consumption was positively associated with creatinine-adjusted urinary total arsenic (β=0.041, 95% CI: 0.032-0.051) and urinary total arsenic with statistical adjustment for creatinine in the model (β=0.043, 95% CI: 0.032-0.053). Additionally, we observed a significant trend in skin lesion prevalence (P-trend=0.007) and a moderate trend in skin lesion incidence (P-trend=0.07) associated with increased intake of steamed rice. This study suggests that rice intake may be a source of arsenic exposure beyond drinking water.
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影响因子：
0.9
作者：
Chizmar, JF
通讯作者：
Chizmar, JF
影响因子：
9.8
作者：
He, Yi;Zheng, Yan
通讯作者：
Zheng, Yan
影响因子：
10.4
作者：
Juhasz AL;Smith E;Weber J;Rees M;Rofe A;Kuchel T;Sansom L;Naidu R
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Naidu R
影响因子：
168.9
作者：
Bae, M;Watanabe, C;Ohtsuka, R
通讯作者：
Ohtsuka, R
DOI：
10.1038/sj.jea.7500449
发表时间：
2006-03-01
影响因子：
4.5
作者：
Ahsan, H;Chen, Y;Graziano, J
通讯作者：
Graziano, J