Immune changes and dysphoric moods across the postpartum.
Immune changes and dysphoric moods across the postpartum.
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DOI：
10.1111/aji.12322
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Ji M
中科院分区：
文献类型：
--
作者：
Groer ME;Jevitt C;Ji M
人们对产后免疫恢复以及常见烦躁情绪、压力、免疫学和内分泌学之间的关系知之甚少。对健康女性 (n=72) 进行为期六个月的产后跟踪，包括免疫和激素测量以及烦躁情绪和压力量表。每次测量丝裂原刺激的全血测定中产生的一组细胞因子，以及 hsC 反应蛋白 (hsCRP)、白细胞介素 6 (IL-6) 和一组激素的血浆水平。通过受刺激的全血培养物产生的干扰素-γ (IFNγ) 和白介素-2 (IL-2) 来测量细胞免疫，在产后早期较低，并在 3 个月内发生变化。肿瘤坏死因子 α (TNFα) 也显示出类似的模式。C 反应蛋白和白介素-6 (IL-6) 的血浆水平在产后早期显示出较高水平。产后情绪障碍评分下降，斜率变化为3 个月。未发现免疫、内分泌和心理社会指标之间存在显着关系。产后可能需要 3 至 4 个月才能恢复正常的细胞免疫功能。早期免疫学的某些方面（hsCRP 和 IL-6）可能反映了妊娠后期、分娩压力和与复旧相关的炎症情绪在产后早期较高，但与免疫因素或激素无关。
Little is known about postpartum immune recovery and relationships of common dysphoric moods, stress, immunology and endocrinology. Healthy women (n=72) were followed for six postpartum months with immune and hormone measures and dysphoric moods and stress scales. A panel of cytokines produced in mitogen-stimulated whole blood assays were measured at each time, along with plasma levels of hsC-reactive protein (hsCRP), Interleukin-6 (IL-6), and a panel of hormones. Cellular immunity, measured by production of Interferon-gamma (IFNγ) and (Interleukin-2 (IL-2) from stimulated whole blood culture, was low in the early postpartum with changes by 3 months. Tumor necrosis factor alpha (TNFα) showed a similar pattern. Plasma levels of C-reactive protein and Interleukin-6 (IL-6) showed higher levels in the early postpartum. Mood disturbance scores dropped across the postpartum with a change in slope at 3 months. No significant relationships were found between immune, endocrine, and psychosocial measures. Return to normal cellular immune function may take 3 to 4 months in the postpartum. Some aspects of early immunology (hsCRP and IL-6) probably reflect the latter stage of pregnancy, the stress of birth and the inflammation associated with involution. Dysphoric moods are higher in the early postpartum but are not related to immune factors or hormones.
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影响因子：
4.7
作者：
Schminkey, Donna L.;Groer, Maureen
通讯作者：
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影响因子：
3.8
作者：
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影响因子：
2.5
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5
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通讯作者：
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影响因子：
27.4
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通讯作者：
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