Single-trial discrimination for integrating simultaneous EEG and fMRI: identifying cortical areas contributing to trial-to-trial variability in the auditory oddball task.
Single-trial discrimination for integrating simultaneous EEG and fMRI: identifying cortical areas contributing to trial-to-trial variability in the auditory oddball task.
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DOI：
10.1016/j.neuroimage.2009.03.062
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发表时间：
2009-08-01
期刊：
影响因子：
5.7
通讯作者：
Sajda P
中科院分区：
文献类型：
--
作者：
Goldman RI;Wei CY;Philiastides MG;Gerson AD;Friedman D;Brown TR;Sajda P
听觉怪球任务是一种被广泛研究的刺激范式，用于研究简单目标检测的神经关联。它引出了几个经典的事件相关电位（ERPs），最突出的是P300，它被视为被试检测罕见（目标）刺激的神经关联。虽然试验平均通常用于识别和表征此类erp，但它们的潜伏期和振幅可以在每次试验的基础上变化，反映了潜在神经信息处理的可变性。在此，我们同时记录了听觉怪球任务期间的脑电图和功能磁共振成像（fMRI），并确定了与任务区分脑电图成分的试验间变异性相关的皮层区域。我们方法的独特之处在于一种线性多元方法，用于在特定刺激或反应锁定的时间窗口内识别任务区分成分。我们发现fMRI激活指示了不同的过程，这些过程有助于目标检测期间的单次试验变异性。这些区域不同于使用标准回归器（包括试验平均回归器）发现的区域。特别值得注意的是枕侧复合体（LOC）的强烈激活。当使用传统的事件相关回归器时，看不到LOC。虽然LOC通常与视觉/空间注意力相关，但它在听觉任务中的激活表明，它可能是一个更普遍的注意力网络的一部分，参与分配目标检测和决策的资源。我们的研究结果表明，与fMRI同时获得的EEG成分的试验间变异性可以产生与任务相关的BOLD激活，否则使用传统的fMRI分析是无法观察到的。
The auditory oddball task is a well-studied stimulus paradigm used to investigate the neural correlates of simple target detection. It elicits several classic event-related potentials (ERPs), the most prominent being the P300 which is seen as a neural correlate of subjects' detection of rare (target) stimuli. Though trial-averaging is typically used to identify and characterize such ERPs, their latency and amplitude can vary on a trial-to-trial basis reflecting variability in the underlying neural information processing. Here we simultaneously recorded EEG and fMRI during an auditory oddball task and identified cortical areas correlated with the trial-to-trial variability of task-discriminating EEG components. Unique to our approach is a linear multivariate method for identifying task-discriminating components within specific stimulus- or response- locked time windows. We find fMRI activations indicative of distinct processes that contribute to the single-trial variability during target detection. These regions are different from those found using standard, including trial-averaged, regressors. Of particular note is strong activation of the lateral occipital complex (LOC). The LOC was not seen when using traditional event-related regressors. Though LOC is typically associated with visual/spatial attention, its activation in an auditory oddball task, where attention can wax and wane from trial-to-trial, indicates it may be part of a more general attention network involved in allocating resources for target detection and decision making. Our results show that trial-to-trial variability in EEG components, acquired simultaneously with fMRI, can yield task-relevant BOLD activations that are otherwise unobservable using traditional fMRI analysis.
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