Risk of future depression in people who are obese but metabolically healthy: the English longitudinal study of ageing.
Risk of future depression in people who are obese but metabolically healthy: the English longitudinal study of ageing.
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DOI：
10.1038/mp.2012.30
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发表时间：
2012-09
影响因子：
11
通讯作者：
Kivimaki, M.
中科院分区：
文献类型：
--
作者：
Hamer, M.;Batty, G. D.;Kivimaki, M.
有一些证据表明，肥胖是抑郁症发展的一个危险因素，尽管这不是一个普遍的发现。这种不一致性可能归因于“健康肥胖表型”的存在，即在没有心脏代谢危险因素相关负担的情况下的肥胖。我们研究了肥胖与抑郁症状的关联是否取决于个体的代谢健康。参与者是来自英国老龄化纵向研究的3851名男性和女性（年龄63.0 ± 8.9岁，45.1%男性），这是一项针对社区居住老年人的前瞻性研究。肥胖定义为体重指数≥ 30 kg/m2。根据血压、HDL-胆固醇、甘油三酯、糖化血红蛋白和C-反应蛋白，将参与者分为“代谢健康”（0或1项代谢异常）或“不健康”（≥ 2项代谢异常）。在基线和2年随访时使用流行病学研究中心抑郁量表（CES-D）的8项量表评估抑郁症状。肥胖患病率为27.5%，但该组中有34.3%在基线时被归类为代谢健康。相对于非肥胖的健康受试者，在校正基线CES-D评分和其他协变量后，代谢不健康的肥胖受试者在随访时抑郁症状的风险升高（比值比[OR] = 1.50，95%CI，1.05-2.15），尽管代谢健康的肥胖受试者没有抑郁症状的风险（OR = 1.38，95%CI，0.88-2.17）。肥胖与抑郁症状风险之间的关联似乎部分取决于代谢健康，尽管需要进一步的工作来证实这些发现。
There is some evidence to suggest that obesity is a risk factor for the development of depression, although this is not a universal finding. This discordance might be ascribed to the existence of a ‘healthy obese phenotype’– that is, obesity in the absence of the associated burden of cardio-metabolic risk factors. We examined whether the association of obesity with depressive symptoms is dependent on the individual’s metabolic health. Participants were 3851 men and women (aged 63.0 ± 8.9 yrs, 45.1% men) from the English Longitudinal Study of Ageing, a prospective study of community dwelling older adults. Obesity was defined as body mass index ≥ 30 kg/m2. Based on blood pressure, HDL-cholesterol, triglycerides, glycated haemoglobin, and C-reactive protein, participants were classified as ‘metabolically healthy’ (0 or 1 metabolic abnormality) or ‘unhealthy’ (≥ 2 metabolic abnormalities). Depressive symptoms were assessed at baseline and at 2 years follow up using the 8-item Centre of Epidemiological Studies Depression (CES-D) scale. Obesity prevalence was 27.5%, but 34.3% of this group was categorized as metabolically healthy at baseline. Relative to non-obese healthy participants, after adjustment for baseline CES-D score and other covariates, the metabolically unhealthy obese participants had elevated risk of depressive symptoms at follow-up (odds ratio [OR] = 1.50, 95% CI, 1.05–2.15), although the metabolically healthy obese did not (OR = 1.38, 95% CI, 0.88–2.17). The association between obesity and risk of depressive symptoms appears to be partly dependent on metabolic health, although further work is required to confirm these findings.
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影响因子：
6.7
作者：
Hildrum, B.;Mykletun, A.;Dahl, A. A.
通讯作者：
Dahl, A. A.
肥胖和代谢综合征会增加老年男性患抑郁症的风险：男性健康研究
影响因子：
7.2
作者：
Almeida, Osvaldo P.;Calver, Janine;Flicker, Leon
通讯作者：
Flicker, Leon
影响因子：
10.6
作者：
Dowlati, Yekta;Herrmann, Nathan;Lanctot, Krista L.
通讯作者：
Lanctot, Krista L.
影响因子：
--
作者：
Irwin, M;Artin, KHH;Oxman, MN
通讯作者：
Oxman, MN
影响因子：
4.8
作者：
Koenigsberg, HW;Teicher, MH;Siever, LJ
通讯作者：
Siever, LJ